Effects of carbon nanotubes on human monocytes

Milena De Nicola; Silvia Nuccitelli; Daniele Mirabile Gattia; Enrico Traversa; Andrea Magrini; Antonio Bergamaschi; Lina Ghibelli

doi:10.1111/j.1749-6632.2009.04892.x

Effects of carbon nanotubes on human monocytes

Milena De Nicola^*, Silvia Nuccitelli, Daniele Mirabile Gattia, Enrico Traversa, Andrea Magrini, Antonio Bergamaschi, Lina Ghibelli

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

13 Scopus citations

Abstract

Carbon nanotubes are considered to be one of the novel most attractive materials in nanotechnology. Because of their multiple industrial and biomedical applications, thorough studies on their toxicity and biocompatibility become a priority in order to prevent possible health risks. In this study the effects of multiwalled carbon nanotubes (MWCNT) on healthy monocytes from human peripheral blood were investigated. The results indicate that MWCNT exert a cytotoxic effect on monocytes, inducing cell death and increasing the extent of apoptosis induced by a chemotherapic agent. This cytotoxic effect may have important implications, and much attention in terms of evaluation of exposure risks is recommended.

Original language	English (US)
Title of host publication	Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways
Publisher	Blackwell Publishing Inc.
Pages	600-605
Number of pages	6
ISBN (Print)	9781573317375
DOIs	https://doi.org/10.1111/j.1749-6632.2009.04892.x
State	Published - Aug 2009
Externally published	Yes

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1171
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

Apoptosis
Cytotoxicity
Human monocytes
MWCNT

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Neuroscience
History and Philosophy of Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1749-6632.2009.04892.x

Cite this

De Nicola, M., Nuccitelli, S., Gattia, D. M., Traversa, E., Magrini, A., Bergamaschi, A., & Ghibelli, L. (2009). Effects of carbon nanotubes on human monocytes. In Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways (pp. 600-605). (Annals of the New York Academy of Sciences; Vol. 1171). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.04892.x

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title = "Effects of carbon nanotubes on human monocytes",

abstract = "Carbon nanotubes are considered to be one of the novel most attractive materials in nanotechnology. Because of their multiple industrial and biomedical applications, thorough studies on their toxicity and biocompatibility become a priority in order to prevent possible health risks. In this study the effects of multiwalled carbon nanotubes (MWCNT) on healthy monocytes from human peripheral blood were investigated. The results indicate that MWCNT exert a cytotoxic effect on monocytes, inducing cell death and increasing the extent of apoptosis induced by a chemotherapic agent. This cytotoxic effect may have important implications, and much attention in terms of evaluation of exposure risks is recommended.",

keywords = "Apoptosis, Cytotoxicity, Human monocytes, MWCNT",

author = "{De Nicola}, Milena and Silvia Nuccitelli and Gattia, {Daniele Mirabile} and Enrico Traversa and Andrea Magrini and Antonio Bergamaschi and Lina Ghibelli",

year = "2009",

month = aug,

doi = "10.1111/j.1749-6632.2009.04892.x",

language = "English (US)",

isbn = "9781573317375",

series = "Annals of the New York Academy of Sciences",

publisher = "Blackwell Publishing Inc.",

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}

Effects of carbon nanotubes on human monocytes. / De Nicola, Milena; Nuccitelli, Silvia; Gattia, Daniele Mirabile et al.
Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways. Blackwell Publishing Inc., 2009. p. 600-605 (Annals of the New York Academy of Sciences; Vol. 1171).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Effects of carbon nanotubes on human monocytes

AU - De Nicola, Milena

AU - Nuccitelli, Silvia

AU - Gattia, Daniele Mirabile

AU - Traversa, Enrico

AU - Magrini, Andrea

AU - Bergamaschi, Antonio

AU - Ghibelli, Lina

PY - 2009/8

Y1 - 2009/8

N2 - Carbon nanotubes are considered to be one of the novel most attractive materials in nanotechnology. Because of their multiple industrial and biomedical applications, thorough studies on their toxicity and biocompatibility become a priority in order to prevent possible health risks. In this study the effects of multiwalled carbon nanotubes (MWCNT) on healthy monocytes from human peripheral blood were investigated. The results indicate that MWCNT exert a cytotoxic effect on monocytes, inducing cell death and increasing the extent of apoptosis induced by a chemotherapic agent. This cytotoxic effect may have important implications, and much attention in terms of evaluation of exposure risks is recommended.

AB - Carbon nanotubes are considered to be one of the novel most attractive materials in nanotechnology. Because of their multiple industrial and biomedical applications, thorough studies on their toxicity and biocompatibility become a priority in order to prevent possible health risks. In this study the effects of multiwalled carbon nanotubes (MWCNT) on healthy monocytes from human peripheral blood were investigated. The results indicate that MWCNT exert a cytotoxic effect on monocytes, inducing cell death and increasing the extent of apoptosis induced by a chemotherapic agent. This cytotoxic effect may have important implications, and much attention in terms of evaluation of exposure risks is recommended.

KW - Apoptosis

KW - Cytotoxicity

KW - Human monocytes

KW - MWCNT

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U2 - 10.1111/j.1749-6632.2009.04892.x

DO - 10.1111/j.1749-6632.2009.04892.x

M3 - Conference contribution

C2 - 19723110

AN - SCOPUS:69149098836

SN - 9781573317375

T3 - Annals of the New York Academy of Sciences

SP - 600

EP - 605

BT - Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways

PB - Blackwell Publishing Inc.

ER -

Effects of carbon nanotubes on human monocytes

Abstract

Publication series

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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