Efficient and Highly Aldehyde Selective Wacker Oxidation

Peili Teo, Zachary K. Wickens, Guangbin Dong, Robert H. Grubbs

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


A method for efficient and aldehyde-selective Wacker oxidation of aryl-substituted olefins using PdCl 2(MeCN) 2, 1,4-benzoquinone, and t-BuOH in air is described. Up to a 96% yield of aldehyde can be obtained, and up to 99% selectivity can be achieved with styrene-related substrates. © 2012 American Chemical Society.
Original languageEnglish (US)
Pages (from-to)3237-3239
Number of pages3
JournalOrganic Letters
Issue number13
StatePublished - Jun 13 2012
Externally publishedYes


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