Efficient enantioselective synthesis of optically active diols by asymmetric hydrogénation with modular chiral metal catalysts

Renat Kadyrov; René M. Koenigs; Claus Brinkmann; David Voigtlaender; Magnus Rueping

doi:10.1002/anie.200902835

Efficient enantioselective synthesis of optically active diols by asymmetric hydrogénation with modular chiral metal catalysts

Renat Kadyrov^*, René M. Koenigs, Claus Brinkmann, David Voigtlaender, Magnus Rueping

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Valuable vicinal 1,2-diols can be prepared with high enantioselectivity by the asymmetric ruthenium-catalyzed hydrogenation of aryl- and alkyl-substituted -hydroxy ketones (see scheme). The ligands, which are distinguished by their modular construction, display excellent enantioface differentiation.

Original language	English (US)
Pages (from-to)	7556-7559
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	41
DOIs	https://doi.org/10.1002/anie.200902835
State	Published - Sep 28 2009
Externally published	Yes

Keywords

Asymmetric synthesis
Diols
Hydrogenation
Phosphanes
Ruthenium complexes

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200902835

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abstract = "Valuable vicinal 1,2-diols can be prepared with high enantioselectivity by the asymmetric ruthenium-catalyzed hydrogenation of aryl- and alkyl-substituted -hydroxy ketones (see scheme). The ligands, which are distinguished by their modular construction, display excellent enantioface differentiation.",

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author = "Renat Kadyrov and Koenigs, {Ren{\'e} M.} and Claus Brinkmann and David Voigtlaender and Magnus Rueping",

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AU - Kadyrov, Renat

AU - Koenigs, René M.

AU - Brinkmann, Claus

AU - Voigtlaender, David

AU - Rueping, Magnus

PY - 2009/9/28

Y1 - 2009/9/28

N2 - Valuable vicinal 1,2-diols can be prepared with high enantioselectivity by the asymmetric ruthenium-catalyzed hydrogenation of aryl- and alkyl-substituted -hydroxy ketones (see scheme). The ligands, which are distinguished by their modular construction, display excellent enantioface differentiation.

AB - Valuable vicinal 1,2-diols can be prepared with high enantioselectivity by the asymmetric ruthenium-catalyzed hydrogenation of aryl- and alkyl-substituted -hydroxy ketones (see scheme). The ligands, which are distinguished by their modular construction, display excellent enantioface differentiation.

KW - Asymmetric synthesis

KW - Diols

KW - Hydrogenation

KW - Phosphanes

KW - Ruthenium complexes

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M3 - Article

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AN - SCOPUS:70349991011

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Efficient enantioselective synthesis of optically active diols by asymmetric hydrogénation with modular chiral metal catalysts

Abstract

Keywords

ASJC Scopus subject areas

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