TY - JOUR
T1 - Einkorn genomics sheds light on history of the oldest domesticated wheat
AU - Ahmed, Hanin
AU - Heuberger, Matthias
AU - Schoen, Adam
AU - Koo, Dal-Hoe
AU - Quiroz-Chávez, Jesús
AU - Adhikari, Laxman
AU - Raupp, John
AU - Cauet, Stéphane
AU - Rodde, Nathalie
AU - Cravero, Charlotte
AU - Callot, Caroline
AU - Lazo, Gerard R.
AU - Kathiresan, Nagarajan
AU - Sharma, Parva K.
AU - Moot, Ian
AU - Yadav, Inderjit Singh
AU - Singh, Lovepreet
AU - Saripalli, Gautam
AU - Rawat, Nidhi
AU - Datla, Raju
AU - Athiyannan, Naveenkumar
AU - Ramirez-Gonzalez, Ricardo H.
AU - Uauy, Cristobal
AU - Wicker, Thomas
AU - Tiwari, Vijay
AU - Abrouk, Michael
AU - Poland, Jesse
AU - Krattinger, Simon G.
N1 - KAUST Repository Item: Exported on 2023-08-07
Acknowledgements: We thank the members of the KAUST Bioscience Core Laboratory for sequencing support; E. Cavalet-Giorsa for providing information on einkorn domestication and migration; L. Aouini for assistance with RNA extraction; L. Zou for greenhouse support; B. Gill for providing seeds of the tin3 mutant; and T. Quilichini for SEM images. We acknowledge support by the plant growth facility and the GENTYANE platform of the Clermont-Ferrand INRAE Centre for assisting in NGS sequencing; the Genotoul bioinformatics platform Toulouse Midi-Pyrenees (Bioinfo Genotoul, http://bioinfo.genotoul.fr) and the KAUST supercomputing facilities (https://www.hpc.kaust.edu.sa) for providing computing resources; GrainGenes resources for hosting the online database; and the University of Maryland supercomputing resources (http://hpcc.umd.edu) for developing the einkorn database and tin3 analysis. This publication is based on work supported by the King Abdullah University of Science and Technology, the UK Biotechnology and Biological Sciences Research Council (BBSRC; BB/P016855/1), the Mexican Consejo Nacional de Ciencia y Tecnología (CONACYT; 2018-000009-01EXTF-00306), the Global Institute for Food Security (to R.D.), the European Research Council (ERC-2019-COG-866328) and the United States Department of Agriculture National Institute of Food and Agriculture (USDA-NIFA; award 2020-67013-31460). D.-H.K. was supported by WGRC/IUCRC and NSF (grant 1822162).
PY - 2023/8/2
Y1 - 2023/8/2
N2 - Einkorn (Triticum monococcum) was the first domesticated wheat species, and was central to the birth of agriculture and the Neolithic Revolution in the Fertile Crescent around 10,000 years ago1,2. Here we generate and analyse 5.2-Gb genome assemblies for wild and domesticated einkorn, including completely assembled centromeres. Einkorn centromeres are highly dynamic, showing evidence of ancient and recent centromere shifts caused by structural rearrangements. Whole-genome sequencing analysis of a diversity panel uncovered the population structure and evolutionary history of einkorn, revealing complex patterns of hybridizations and introgressions after the dispersal of domesticated einkorn from the Fertile Crescent. We also show that around 1% of the modern bread wheat (Triticum aestivum) A subgenome originates from einkorn. These resources and findings highlight the history of einkorn evolution and provide a basis to accelerate the genomics-assisted improvement of einkorn and bread wheat.
AB - Einkorn (Triticum monococcum) was the first domesticated wheat species, and was central to the birth of agriculture and the Neolithic Revolution in the Fertile Crescent around 10,000 years ago1,2. Here we generate and analyse 5.2-Gb genome assemblies for wild and domesticated einkorn, including completely assembled centromeres. Einkorn centromeres are highly dynamic, showing evidence of ancient and recent centromere shifts caused by structural rearrangements. Whole-genome sequencing analysis of a diversity panel uncovered the population structure and evolutionary history of einkorn, revealing complex patterns of hybridizations and introgressions after the dispersal of domesticated einkorn from the Fertile Crescent. We also show that around 1% of the modern bread wheat (Triticum aestivum) A subgenome originates from einkorn. These resources and findings highlight the history of einkorn evolution and provide a basis to accelerate the genomics-assisted improvement of einkorn and bread wheat.
UR - http://hdl.handle.net/10754/693480
UR - https://www.nature.com/articles/s41586-023-06389-7
U2 - 10.1038/s41586-023-06389-7
DO - 10.1038/s41586-023-06389-7
M3 - Article
C2 - 37532937
SN - 0028-0836
JO - Nature
JF - Nature
ER -