Enantiospecific kinking of DNA by a partially intercalating metal complex

Anna Reymer; Bengt Nordén

doi:10.1039/c2cc31176c

Enantiospecific kinking of DNA by a partially intercalating metal complex

Anna Reymer, Bengt Nordén

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Opposite enantiomers of [Ru(phenanthroline) 3] 2+ affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins. © The Royal Society of Chemistry 2012.

Original language	English (US)
Pages (from-to)	4941
Journal	Chemical Communications
Volume	48
Issue number	41
DOIs	https://doi.org/10.1039/c2cc31176c
State	Published - 2012
Externally published	Yes

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title = "Enantiospecific kinking of DNA by a partially intercalating metal complex",

abstract = "Opposite enantiomers of [Ru(phenanthroline) 3] 2+ affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins. {\textcopyright} The Royal Society of Chemistry 2012.",

author = "Anna Reymer and Bengt Nord{\'e}n",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): KUK-11-008-23 Acknowledgements: This work was supported by King Abdullah University of Science and Technology, Grant [KUK-11-008-23] awarded to B.N. This publication acknowledges KAUST support, but has no KAUST affiliated authors.",

year = "2012",

doi = "10.1039/c2cc31176c",

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volume = "48",

pages = "4941",

journal = "Chemical Communications",

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T1 - Enantiospecific kinking of DNA by a partially intercalating metal complex

AU - Reymer, Anna

AU - Nordén, Bengt

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): KUK-11-008-23 Acknowledgements: This work was supported by King Abdullah University of Science and Technology, Grant [KUK-11-008-23] awarded to B.N. This publication acknowledges KAUST support, but has no KAUST affiliated authors.

PY - 2012

Y1 - 2012

N2 - Opposite enantiomers of [Ru(phenanthroline) 3] 2+ affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins. © The Royal Society of Chemistry 2012.

AB - Opposite enantiomers of [Ru(phenanthroline) 3] 2+ affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins. © The Royal Society of Chemistry 2012.

UR - http://hdl.handle.net/10754/598163

UR - http://xlink.rsc.org/?DOI=c2cc31176c

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DO - 10.1039/c2cc31176c

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SN - 1359-7345

VL - 48

SP - 4941

JO - Chemical Communications

JF - Chemical Communications

IS - 41

ER -

Enantiospecific kinking of DNA by a partially intercalating metal complex

Abstract

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