Enhancing the bioavailability of mebendazole by integrating the principles solid dispersion and nanocrystal techniques, for safe and effective management of human echinococcosis

Sushant Chaudhary, Tarun Garg, Goutam Rath, Rs Rayasa Murthy, Amit K. Goyal

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The method based on integrating the principles of solid dispersion and nanocrystal techniques was developed to prepare polymer crystals (PCs) of mebendazole (MBZ) and polyethylene glycol (PEG). Powder X-Ray diffraction (PXRD) of the PC crystals shows the required integrated crystalline and amorphous regions. The in vitro solubility studies showed a 32-fold increase in the solubility of the drug. Tests of dissolution of the PCs showed that the crystals have an enhanced dissolution rate in comparison to those in the MF. The results of the pharmacokinetic study showed a 2.12-fold increase in the bioavailability of the drug. Thus, the present study has proved the potential in enhancing solubility, dissolution, and bioavailability of the drug.
Original languageEnglish (US)
Pages (from-to)937-942
Number of pages6
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume44
Issue number3
DOIs
StatePublished - Apr 2 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Pharmaceutical Science
  • Medicine (miscellaneous)

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