Enzymatic ligation creates discrete multinanoparticle building blocks for self-assembly

Shelley A. Claridge, Alexander J. Mastroianni, Yeung B. Au, Huiyang W. Liang, Christine M. Micheel, Jean M.J. Fréchet, A. Paul Alivisatos

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Enzymatic ligation of discrete nanoparticle-DNA conjugates creates nanoparticle dimer and trimer structures in which the nanoparticles are linked by single-stranded DNA, rather than by double-stranded DNA as in previous experiments. Ligation was verified by agarose gel and small-angle X-ray scattering. This capability was utilized in two ways: first, to create a new class of multiparticle building blocks for nanoscale self-assembly and, second, to develop a system that can amplify a population of discrete nanoparticle assemblies.

Original languageEnglish (US)
Pages (from-to)9598-9605
Number of pages8
JournalJournal of the American Chemical Society
Issue number29
StatePublished - Jul 23 2008
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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