Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging

Yevhen Fatieiev; Jonas G. Croissant; Khachatur Julfakyan; Lin Deng; Dalaver H. Anjum; Andrei Gurinov; Niveen M. Khashab

doi:10.1039/C5NR03065J

Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging

Yevhen Fatieiev, Jonas G. Croissant, Khachatur Julfakyan, Lin Deng, Dalaver H. Anjum, Andrei Gurinov, Niveen M. Khashab

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Non-aggregated dense bridged silsesquioxane (BS) nanoparticles based on nature-inspired oxamide bridges are shown to degrade in simulated biological media upon cleavage with endopeptidase. Fluorescent BS nanoprobes with incorporated fluorescein dyes were applied for in-vitro imaging in cancer cells.

Original language	English (US)
Pages (from-to)	15046-15050
Number of pages	5
Journal	Nanoscale
Volume	7
Issue number	37
DOIs	https://doi.org/10.1039/C5NR03065J
State	Published - 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/C5NR03065J

https://repository.kaust.edu.sa/bitstream/10754/558874/1/C5NR03065J.pdf

Cite this

@article{ddee568c10c745bd92e7c669fb9e9b27,

title = "Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging",

abstract = "Non-aggregated dense bridged silsesquioxane (BS) nanoparticles based on nature-inspired oxamide bridges are shown to degrade in simulated biological media upon cleavage with endopeptidase. Fluorescent BS nanoprobes with incorporated fluorescein dyes were applied for in-vitro imaging in cancer cells.",

author = "Yevhen Fatieiev and Croissant, {Jonas G.} and Khachatur Julfakyan and Lin Deng and Anjum, {Dalaver H.} and Andrei Gurinov and Khashab, {Niveen M.}",

note = "KAUST Repository Item: Exported on 2020-10-01",

year = "2015",

doi = "10.1039/C5NR03065J",

language = "English (US)",

volume = "7",

pages = "15046--15050",

journal = "Nanoscale",

issn = "2040-3364",

publisher = "Royal Society of Chemistry",

number = "37",

}

TY - JOUR

T1 - Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging

AU - Fatieiev, Yevhen

AU - Croissant, Jonas G.

AU - Julfakyan, Khachatur

AU - Deng, Lin

AU - Anjum, Dalaver H.

AU - Gurinov, Andrei

AU - Khashab, Niveen M.

N1 - KAUST Repository Item: Exported on 2020-10-01

PY - 2015

Y1 - 2015

N2 - Non-aggregated dense bridged silsesquioxane (BS) nanoparticles based on nature-inspired oxamide bridges are shown to degrade in simulated biological media upon cleavage with endopeptidase. Fluorescent BS nanoprobes with incorporated fluorescein dyes were applied for in-vitro imaging in cancer cells.

AB - Non-aggregated dense bridged silsesquioxane (BS) nanoparticles based on nature-inspired oxamide bridges are shown to degrade in simulated biological media upon cleavage with endopeptidase. Fluorescent BS nanoprobes with incorporated fluorescein dyes were applied for in-vitro imaging in cancer cells.

UR - http://hdl.handle.net/10754/558874

UR - http://pubs.rsc.org/en/Content/ArticleLanding/2015/NR/C5NR03065J

UR - http://www.scopus.com/inward/record.url?scp=84942134519&partnerID=8YFLogxK

U2 - 10.1039/C5NR03065J

DO - 10.1039/C5NR03065J

M3 - Article

C2 - 26165456

SN - 2040-3364

VL - 7

SP - 15046

EP - 15050

JO - Nanoscale

JF - Nanoscale

IS - 37

ER -

Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this