Epigenetic Mechanisms that Regulate Cell Identity

María J. Barrero; Stephanie Boué; Juan Carlos Izpisúa Belmonte

doi:10.1016/j.stem.2010.10.009

Epigenetic Mechanisms that Regulate Cell Identity

María J. Barrero, Stephanie Boué, Juan Carlos Izpisúa Belmonte

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

Abstract

Individual cell fate decisions can vary according to changes in gene expression in response to environmental, developmental, or metabolic cues. This plasticity is tightly regulated during embryonic development and mediated by the exquisitely coordinated activation and repression of groups of genes. Genes that become repressed are immersed in a condensed chromatin environment that renders them refractory to stimulation. This mechanism is responsible for both the loss of cell plasticity during differentiation and the preservation of cell identity. Understanding the molecular events involved in the establishment and maintenance of these restrictive domains will benefit the design of strategies for cellular reprogramming, differentiation, and cancer treatment.

Original language	English (US)
Pages (from-to)	565-570
Number of pages	6
Journal	Cell Stem Cell
Volume	7
Issue number	5
DOIs	https://doi.org/10.1016/j.stem.2010.10.009
State	Published - Nov 5 2010
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.stem.2010.10.009

Cite this

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title = "Epigenetic Mechanisms that Regulate Cell Identity",

abstract = "Individual cell fate decisions can vary according to changes in gene expression in response to environmental, developmental, or metabolic cues. This plasticity is tightly regulated during embryonic development and mediated by the exquisitely coordinated activation and repression of groups of genes. Genes that become repressed are immersed in a condensed chromatin environment that renders them refractory to stimulation. This mechanism is responsible for both the loss of cell plasticity during differentiation and the preservation of cell identity. Understanding the molecular events involved in the establishment and maintenance of these restrictive domains will benefit the design of strategies for cellular reprogramming, differentiation, and cancer treatment.",

author = "Barrero, {Mar{\'i}a J.} and Stephanie Bou{\'e} and {Izpis{\'u}a Belmonte}, {Juan Carlos}",

note = "Funding Information: We apologize for those authors whose work could not be cited because of space limitation. We would like to thank all the members of the J.C.I.B. lab at The Salk Institute for Biological Studies and the CMRB for their insightful comments and input. This work was partially supported by grants RYC-2007-01510 and SAF2009-08588 from the Ministerio de Ciencia e Innovaci{\'o}n of Spain to M.J.B. and grants from the G. Harold and Leila Y. Mathers Charitable and Cellex Foundations, Sanofi-Aventis, and MICINN to J.C.I.B.",

year = "2010",

month = nov,

day = "5",

doi = "10.1016/j.stem.2010.10.009",

language = "English (US)",

volume = "7",

pages = "565--570",

journal = "Cell Stem Cell",

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AU - Barrero, María J.

AU - Boué, Stephanie

AU - Izpisúa Belmonte, Juan Carlos

N1 - Funding Information: We apologize for those authors whose work could not be cited because of space limitation. We would like to thank all the members of the J.C.I.B. lab at The Salk Institute for Biological Studies and the CMRB for their insightful comments and input. This work was partially supported by grants RYC-2007-01510 and SAF2009-08588 from the Ministerio de Ciencia e Innovación of Spain to M.J.B. and grants from the G. Harold and Leila Y. Mathers Charitable and Cellex Foundations, Sanofi-Aventis, and MICINN to J.C.I.B.

PY - 2010/11/5

Y1 - 2010/11/5

N2 - Individual cell fate decisions can vary according to changes in gene expression in response to environmental, developmental, or metabolic cues. This plasticity is tightly regulated during embryonic development and mediated by the exquisitely coordinated activation and repression of groups of genes. Genes that become repressed are immersed in a condensed chromatin environment that renders them refractory to stimulation. This mechanism is responsible for both the loss of cell plasticity during differentiation and the preservation of cell identity. Understanding the molecular events involved in the establishment and maintenance of these restrictive domains will benefit the design of strategies for cellular reprogramming, differentiation, and cancer treatment.

AB - Individual cell fate decisions can vary according to changes in gene expression in response to environmental, developmental, or metabolic cues. This plasticity is tightly regulated during embryonic development and mediated by the exquisitely coordinated activation and repression of groups of genes. Genes that become repressed are immersed in a condensed chromatin environment that renders them refractory to stimulation. This mechanism is responsible for both the loss of cell plasticity during differentiation and the preservation of cell identity. Understanding the molecular events involved in the establishment and maintenance of these restrictive domains will benefit the design of strategies for cellular reprogramming, differentiation, and cancer treatment.

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U2 - 10.1016/j.stem.2010.10.009

DO - 10.1016/j.stem.2010.10.009

M3 - Review article

C2 - 21040898

AN - SCOPUS:78049495115

SN - 1934-5909

VL - 7

SP - 565

EP - 570

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 5

ER -

Epigenetic Mechanisms that Regulate Cell Identity

Abstract

ASJC Scopus subject areas

UN SDGs

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