Establishing a left-right axis in the embryo

Aimee K. Ryan*, Juan Carlos Izpisúa Belmonte

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Vertebrates exhibit evolutionarily conserved asymmetries in the pattern of internal organ placement that are essential for their normal physiological function. Left-right asymmetries in organ situs are dependent upon the formation of an intact left-right axis during embryogenesis. Recently many of the molecular components involved in the initiation and maintenance of the left-right axis have been described. These molecules and their function in promoting left-right asymmetries are reviewed.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalIUBMB Life
Issue number1
StatePublished - 2000
Externally publishedYes


  • Asymmetry
  • Left-right axis
  • Organ situs

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology


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