Establishing a left-right axis in the embryo

Aimee K. Ryan; Juan Carlos Izpisúa Belmonte

doi:10.1080/15216540050176520

Establishing a left-right axis in the embryo

Aimee K. Ryan^*, Juan Carlos Izpisúa Belmonte

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Vertebrates exhibit evolutionarily conserved asymmetries in the pattern of internal organ placement that are essential for their normal physiological function. Left-right asymmetries in organ situs are dependent upon the formation of an intact left-right axis during embryogenesis. Recently many of the molecular components involved in the initiation and maintenance of the left-right axis have been described. These molecules and their function in promoting left-right asymmetries are reviewed.

Original language	English (US)
Pages (from-to)	1-11
Number of pages	11
Journal	IUBMB Life
Volume	50
Issue number	1
DOIs	https://doi.org/10.1080/15216540050176520
State	Published - 2000
Externally published	Yes

Keywords

Asymmetry
Left-right axis
Organ situs

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics
Clinical Biochemistry
Cell Biology

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10.1080/15216540050176520

Cite this

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title = "Establishing a left-right axis in the embryo",

abstract = "Vertebrates exhibit evolutionarily conserved asymmetries in the pattern of internal organ placement that are essential for their normal physiological function. Left-right asymmetries in organ situs are dependent upon the formation of an intact left-right axis during embryogenesis. Recently many of the molecular components involved in the initiation and maintenance of the left-right axis have been described. These molecules and their function in promoting left-right asymmetries are reviewed.",

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AU - Ryan, Aimee K.

AU - Belmonte, Juan Carlos Izpisúa

PY - 2000

Y1 - 2000

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AB - Vertebrates exhibit evolutionarily conserved asymmetries in the pattern of internal organ placement that are essential for their normal physiological function. Left-right asymmetries in organ situs are dependent upon the formation of an intact left-right axis during embryogenesis. Recently many of the molecular components involved in the initiation and maintenance of the left-right axis have been described. These molecules and their function in promoting left-right asymmetries are reviewed.

KW - Asymmetry

KW - Left-right axis

KW - Organ situs

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U2 - 10.1080/15216540050176520

DO - 10.1080/15216540050176520

M3 - Review article

C2 - 11087114

AN - SCOPUS:0033785344

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JF - IUBMB Life

IS - 1

ER -

Establishing a left-right axis in the embryo

Abstract

Keywords

ASJC Scopus subject areas

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