TY - JOUR
T1 - Evaluation of anti-GERD activity of gastro retentive drug delivery system of itopride hydrochloride
AU - Satapathy, Trilochan
AU - Panda, Prasana K.
AU - Goyal, Amit K.
AU - Rath, Goutam
N1 - Generated from Scopus record by KAUST IRTS on 2023-10-12
PY - 2010/8/1
Y1 - 2010/8/1
N2 - The present work describes the formulation and evaluation of the gastroretentive system of Itopride hydrochloride. In this research, we have formulated floating hydrogel-based microspheres employing calcium carbonate (CaCO3) as a gas forming agent dispersed in alginate matrix. In vitro characterizations such as drug content, particle size, and drug release were carried out. GI motility was determined by administration of charcoal meal to rats. Results demonstrated that prepared microspheres were spherical in shape with smooth surface, good loading efficiency, and excellent buoyancy. The gastro retentive dosage form of itiopride demonstrated significant antacid, anti-ulcer, and anti-GERD activity after 12 hours in comparison with the conventional dosage form. © 2010 Informa UK Ltd.
AB - The present work describes the formulation and evaluation of the gastroretentive system of Itopride hydrochloride. In this research, we have formulated floating hydrogel-based microspheres employing calcium carbonate (CaCO3) as a gas forming agent dispersed in alginate matrix. In vitro characterizations such as drug content, particle size, and drug release were carried out. GI motility was determined by administration of charcoal meal to rats. Results demonstrated that prepared microspheres were spherical in shape with smooth surface, good loading efficiency, and excellent buoyancy. The gastro retentive dosage form of itiopride demonstrated significant antacid, anti-ulcer, and anti-GERD activity after 12 hours in comparison with the conventional dosage form. © 2010 Informa UK Ltd.
UR - http://www.tandfonline.com/doi/full/10.3109/10731191003776751
UR - http://www.scopus.com/inward/record.url?scp=77954770344&partnerID=8YFLogxK
U2 - 10.3109/10731191003776751
DO - 10.3109/10731191003776751
M3 - Article
SN - 1073-1199
VL - 38
SP - 200
EP - 207
JO - Artificial Cells, Blood Substitutes, and Biotechnology
JF - Artificial Cells, Blood Substitutes, and Biotechnology
IS - 4
ER -