TY - GEN
T1 - Evaluation of the relation between changes in R-wave amplitude and LV mass and dimensions in a model of 'Reversed Hypertrophy'
AU - Caiani, Enrico G.
AU - Auricchio, Angelo
AU - Potse, Mark
AU - Krause, Rolf
AU - Pellegrini, Alessandro
AU - Lang, Roberto M.
AU - Vaida, Pierre
PY - 2013
Y1 - 2013
N2 - Electrocardiographic (ECG) diagnosis of left ventricular (LV) hypertrophy, based on the so-called voltage criteria, suffers from low sensitivity, so that the dominant cardiac factors influencing the QRS voltage have not been fully elucidated. Our aim was to evaluate the correlation between changes in R-wave amplitude (R-AMP) and LV mass and size in a model of 'reversed hypertrophy', such as that induced by 5-days head-down (6°) bed rest (HDBR). ECG Holter-24h and echocardiographic imaging were obtained before (PRE) and on the last day (HDT5) of HDBR in 11 male subjects (age 21÷41 years).The R-AMP derived from the vectorcardiogram was correlated with the echo-derived LV mass, end-diastolic (EDV), systolic (ESV) and stroke (SV) volumes. Linear regression between R-AMP and ESV (y=.013R+26, r2=.31) was found significant (p<.05), while regression with LV mass (y=.195R+83, r2=.19, p=.04) was weaker. Further studies using electrophysiologic models could better elucidate the phenomenon.
AB - Electrocardiographic (ECG) diagnosis of left ventricular (LV) hypertrophy, based on the so-called voltage criteria, suffers from low sensitivity, so that the dominant cardiac factors influencing the QRS voltage have not been fully elucidated. Our aim was to evaluate the correlation between changes in R-wave amplitude (R-AMP) and LV mass and size in a model of 'reversed hypertrophy', such as that induced by 5-days head-down (6°) bed rest (HDBR). ECG Holter-24h and echocardiographic imaging were obtained before (PRE) and on the last day (HDT5) of HDBR in 11 male subjects (age 21÷41 years).The R-AMP derived from the vectorcardiogram was correlated with the echo-derived LV mass, end-diastolic (EDV), systolic (ESV) and stroke (SV) volumes. Linear regression between R-AMP and ESV (y=.013R+26, r2=.31) was found significant (p<.05), while regression with LV mass (y=.195R+83, r2=.19, p=.04) was weaker. Further studies using electrophysiologic models could better elucidate the phenomenon.
UR - http://www.scopus.com/inward/record.url?scp=84894165159&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84894165159
SN - 9781479908844
T3 - Computing in Cardiology
SP - 867
EP - 870
BT - Computing in Cardiology 2013, CinC 2013
T2 - 2013 40th Computing in Cardiology Conference, CinC 2013
Y2 - 22 September 2013 through 25 September 2013
ER -