Evolution of protein-protein interaction network

T. Makino, Takashi Gojobori*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

12 Scopus citations


Protein-protein interactions (PPIs) are one of the most important components of biological networks. It is important to understand the evolutionary process of PPIs in order to elucidate how the evolution of biological networks has contributed to diversification of the existent organisms. We focused on the evolutionary rates of proteins involved with PPIs, because it had been shown that for a given protein-coding gene the number of its PPIs in a biological network was one of the important factors in determining the evolutionary rate of the gene. We studied the evolutionary rates of duplicated gene products that were involved with PPIs, reviewing the current situation of this subject. In addition, we focused on how the evolutionary rates of proteins were influenced by the characteristic features of PPIs. We, then, concluded that the evolutionary rates of the proteins in the PPI networks were strongly influenced by their PPI partners. Finally, we emphasized that evolutionary considerations of the PPI proteins were very important for understanding the building up of the current PPI networks.

Original languageEnglish (US)
Title of host publicationGene and Protein Evolution
EditorsJean-Nicolas Volff
Number of pages17
StatePublished - Dec 1 2007

Publication series

NameGenome Dynamics
ISSN (Print)1660-9263

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics


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