Evolutionary motif and its biological and structural significance

Y. Tateno; K. Ikeo; T. Imanishi; H. Watanabe; T. Endo; Y. Yamaguchi; Y. Suzuki; K. Takahashi; K. Tsunoyama; M. Kawai; Y. Kawanishi; K. Naitou; T. Gojobori

doi:10.1007/pl00000056

Evolutionary motif and its biological and structural significance

Y. Tateno^*, K. Ikeo, T. Imanishi, H. Watanabe, T. Endo, Y. Yamaguchi, Y. Suzuki, K. Takahashi, K. Tsunoyama, M. Kawai, Y. Kawanishi, K. Naitou, T. Gojobori

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We developed a method for multiple alignment of protein sequences. The main feature of this method is that it takes the evolutionary relationships of the proteins in question into account repeatedly for execution, until the relationships and alignment results are in agreement. We then applied this method to the data of the international DNA sequence databases, which are the most comprehensive and updated DNA databases in the world, in order to estimate the 'evolutionary motif' by extensive use of a supercomputer. Though a few problems needed to be solved, we could estimate the length of the motifs in the range of 20 to 200 amino acids, with about 60 the most frequent length. We then discussed their biological and structural significance. We believe that we are now in a position to analyze DNA and protein not only in vivo and in vitro but also in silico.

Original language	English (US)
Pages (from-to)	S38-S43
Journal	Journal of Molecular Evolution
Volume	44
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1007/pl00000056
State	Published - 1997
Externally published	Yes

Keywords

Evolutionary motif
Motif length
Multiple alignment
Window analysis

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics

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10.1007/pl00000056

Cite this

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title = "Evolutionary motif and its biological and structural significance",

abstract = "We developed a method for multiple alignment of protein sequences. The main feature of this method is that it takes the evolutionary relationships of the proteins in question into account repeatedly for execution, until the relationships and alignment results are in agreement. We then applied this method to the data of the international DNA sequence databases, which are the most comprehensive and updated DNA databases in the world, in order to estimate the 'evolutionary motif' by extensive use of a supercomputer. Though a few problems needed to be solved, we could estimate the length of the motifs in the range of 20 to 200 amino acids, with about 60 the most frequent length. We then discussed their biological and structural significance. We believe that we are now in a position to analyze DNA and protein not only in vivo and in vitro but also in silico.",

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author = "Y. Tateno and K. Ikeo and T. Imanishi and H. Watanabe and T. Endo and Y. Yamaguchi and Y. Suzuki and K. Takahashi and K. Tsunoyama and M. Kawai and Y. Kawanishi and K. Naitou and T. Gojobori",

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doi = "10.1007/pl00000056",

language = "English (US)",

volume = "44",

pages = "S38--S43",

journal = "Journal of Molecular Evolution",

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TY - JOUR

T1 - Evolutionary motif and its biological and structural significance

AU - Tateno, Y.

AU - Ikeo, K.

AU - Imanishi, T.

AU - Watanabe, H.

AU - Endo, T.

AU - Yamaguchi, Y.

AU - Suzuki, Y.

AU - Takahashi, K.

AU - Tsunoyama, K.

AU - Kawai, M.

AU - Kawanishi, Y.

AU - Naitou, K.

AU - Gojobori, T.

PY - 1997

Y1 - 1997

N2 - We developed a method for multiple alignment of protein sequences. The main feature of this method is that it takes the evolutionary relationships of the proteins in question into account repeatedly for execution, until the relationships and alignment results are in agreement. We then applied this method to the data of the international DNA sequence databases, which are the most comprehensive and updated DNA databases in the world, in order to estimate the 'evolutionary motif' by extensive use of a supercomputer. Though a few problems needed to be solved, we could estimate the length of the motifs in the range of 20 to 200 amino acids, with about 60 the most frequent length. We then discussed their biological and structural significance. We believe that we are now in a position to analyze DNA and protein not only in vivo and in vitro but also in silico.

AB - We developed a method for multiple alignment of protein sequences. The main feature of this method is that it takes the evolutionary relationships of the proteins in question into account repeatedly for execution, until the relationships and alignment results are in agreement. We then applied this method to the data of the international DNA sequence databases, which are the most comprehensive and updated DNA databases in the world, in order to estimate the 'evolutionary motif' by extensive use of a supercomputer. Though a few problems needed to be solved, we could estimate the length of the motifs in the range of 20 to 200 amino acids, with about 60 the most frequent length. We then discussed their biological and structural significance. We believe that we are now in a position to analyze DNA and protein not only in vivo and in vitro but also in silico.

KW - Evolutionary motif

KW - Motif length

KW - Multiple alignment

KW - Window analysis

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U2 - 10.1007/pl00000056

DO - 10.1007/pl00000056

M3 - Article

C2 - 9395405

AN - SCOPUS:8044257122

SN - 0022-2844

VL - 44

SP - S38-S43

JO - Journal of Molecular Evolution

JF - Journal of Molecular Evolution

IS - SUPPL. 1

ER -

Evolutionary motif and its biological and structural significance

Abstract

Keywords

ASJC Scopus subject areas

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