Abstract
Palladium catalysis induced by visible-light irradiation is a promising tool for promoting unusual chemical transformations. We describe the development of excited-state palladium-catalyzed reductive alkylation of imines with alkyl bromides. The new methodology shows broad functional group tolerance and can additionally be applied in the direct three-component reaction of aldehydes, anilines, and alkyl bromides to give the alkyl amines under mild reaction conditions. Time-resolved photoluminescence experiments allowed the determination of the excited-state reaction kinetics and indicate that the reaction is proceeding via the inner-sphere electron transfer mechanism.
Original language | English (US) |
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Pages (from-to) | 8583-8589 |
Number of pages | 7 |
Journal | Chemical Science |
Volume | 13 |
Issue number | 29 |
DOIs | |
State | Published - Jul 7 2022 |
ASJC Scopus subject areas
- General Chemistry