Excited-state palladium-catalysed reductive alkylation of imines: scope and mechanism

Rajesh Kancherla, Krishnamoorthy Muralirajan, Magnus Rueping*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Palladium catalysis induced by visible-light irradiation is a promising tool for promoting unusual chemical transformations. We describe the development of excited-state palladium-catalyzed reductive alkylation of imines with alkyl bromides. The new methodology shows broad functional group tolerance and can additionally be applied in the direct three-component reaction of aldehydes, anilines, and alkyl bromides to give the alkyl amines under mild reaction conditions. Time-resolved photoluminescence experiments allowed the determination of the excited-state reaction kinetics and indicate that the reaction is proceeding via the inner-sphere electron transfer mechanism.

Original languageEnglish (US)
Pages (from-to)8583-8589
Number of pages7
JournalChemical Science
Issue number29
StatePublished - Jul 7 2022

ASJC Scopus subject areas

  • Chemistry(all)


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