Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients

Donghai Xiong; Guangming Li; Kezhen Li; Qinzi Xu; Zhongjie Pan; Feng Ding; Peter Vedell; Pengyuan Liu; Peng Cui; Xing Hua; Hui Jiang; Yuxin Yin; Ze Zhu; Xiaomian Li; Bin Zhang; Ding Ma; Yian Wang; Ming You

doi:10.1093/carcin/bgs210

Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients

Donghai Xiong, Guangming Li, Kezhen Li, Qinzi Xu, Zhongjie Pan, Feng Ding, Peter Vedell, Pengyuan Liu, Peng Cui, Xing Hua, Hui Jiang, Yuxin Yin, Ze Zhu, Xiaomian Li, Bin Zhang, Ding Ma, Yian Wang, Ming You^*

^*Corresponding author for this work

Biological, Environmental Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Lung cancer has become the top killer among malignant tumors in China and is significantly associated with somatic genetic alterations. We performed exome sequencing of 14 non-small cell lung carcinomas (NSCLCs) with matched adjacent normal lung tissues extracted from Chinese patients. In addition to the lung cancer-related genes (TP53, EGFR, KRAS, PIK3CA, and ROS1), this study revealed "novel" genes not previously implicated in NSCLC. Especially, matrix-remodeling associated 5 was the second most frequently mutated gene in NSCLC (first is TP53). Subsequent Sanger sequencing of matrix-remodeling associated 5 in an additional sample set consisting of 52 paired tumor-normal DNA samples revealed that 15% of Chinese NSCLCs contained somatic mutations in matrix-remodeling associated 5. These findings, together with the results from pathway analysis, strongly indicate that altered extracellular matrix-remodeling may be involved in the etiology of NSCLC.

Original language	English (US)
Pages (from-to)	1797-1805
Number of pages	9
Journal	Carcinogenesis
Volume	33
Issue number	9
DOIs	https://doi.org/10.1093/carcin/bgs210
State	Published - Sep 2012

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/carcin/bgs210

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Xiong, D., Li, G., Li, K., Xu, Q., Pan, Z., Ding, F., Vedell, P., Liu, P., Cui, P., Hua, X., Jiang, H., Yin, Y., Zhu, Z., Li, X., Zhang, B., Ma, D., Wang, Y., & You, M. (2012). Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients. Carcinogenesis, 33(9), 1797-1805. https://doi.org/10.1093/carcin/bgs210

@article{e9991a862a754beaac662636438ce64f,

title = "Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients",

abstract = "Lung cancer has become the top killer among malignant tumors in China and is significantly associated with somatic genetic alterations. We performed exome sequencing of 14 non-small cell lung carcinomas (NSCLCs) with matched adjacent normal lung tissues extracted from Chinese patients. In addition to the lung cancer-related genes (TP53, EGFR, KRAS, PIK3CA, and ROS1), this study revealed {"}novel{"} genes not previously implicated in NSCLC. Especially, matrix-remodeling associated 5 was the second most frequently mutated gene in NSCLC (first is TP53). Subsequent Sanger sequencing of matrix-remodeling associated 5 in an additional sample set consisting of 52 paired tumor-normal DNA samples revealed that 15% of Chinese NSCLCs contained somatic mutations in matrix-remodeling associated 5. These findings, together with the results from pathway analysis, strongly indicate that altered extracellular matrix-remodeling may be involved in the etiology of NSCLC.",

author = "Donghai Xiong and Guangming Li and Kezhen Li and Qinzi Xu and Zhongjie Pan and Feng Ding and Peter Vedell and Pengyuan Liu and Peng Cui and Xing Hua and Hui Jiang and Yuxin Yin and Ze Zhu and Xiaomian Li and Bin Zhang and Ding Ma and Yian Wang and Ming You",

note = "Funding Information: This work was supported in part by the National Institutes of Health (grant nos. 7R01AT003203, 7R01AT005522, 5R01CA134433, 5R01CA134682, 5R01CA113793, and 5R01CA129533) and Advancing a Healthier Wisconsin Fund. The authors thank Gary D. Stoner, Michael James, Haris Vikis, and Jay Tichelaar for their comments on the manuscript.",

year = "2012",

month = sep,

doi = "10.1093/carcin/bgs210",

language = "English (US)",

volume = "33",

pages = "1797--1805",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

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Xiong, D, Li, G, Li, K, Xu, Q, Pan, Z, Ding, F, Vedell, P, Liu, P, Cui, P, Hua, X, Jiang, H, Yin, Y, Zhu, Z, Li, X, Zhang, B, Ma, D, Wang, Y & You, M 2012, 'Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients', Carcinogenesis, vol. 33, no. 9, pp. 1797-1805. https://doi.org/10.1093/carcin/bgs210

TY - JOUR

T1 - Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients

AU - Xiong, Donghai

AU - Li, Guangming

AU - Li, Kezhen

AU - Xu, Qinzi

AU - Pan, Zhongjie

AU - Ding, Feng

AU - Vedell, Peter

AU - Liu, Pengyuan

AU - Cui, Peng

AU - Hua, Xing

AU - Jiang, Hui

AU - Yin, Yuxin

AU - Zhu, Ze

AU - Li, Xiaomian

AU - Zhang, Bin

AU - Ma, Ding

AU - Wang, Yian

AU - You, Ming

N1 - Funding Information: This work was supported in part by the National Institutes of Health (grant nos. 7R01AT003203, 7R01AT005522, 5R01CA134433, 5R01CA134682, 5R01CA113793, and 5R01CA129533) and Advancing a Healthier Wisconsin Fund. The authors thank Gary D. Stoner, Michael James, Haris Vikis, and Jay Tichelaar for their comments on the manuscript.

PY - 2012/9

Y1 - 2012/9

N2 - Lung cancer has become the top killer among malignant tumors in China and is significantly associated with somatic genetic alterations. We performed exome sequencing of 14 non-small cell lung carcinomas (NSCLCs) with matched adjacent normal lung tissues extracted from Chinese patients. In addition to the lung cancer-related genes (TP53, EGFR, KRAS, PIK3CA, and ROS1), this study revealed "novel" genes not previously implicated in NSCLC. Especially, matrix-remodeling associated 5 was the second most frequently mutated gene in NSCLC (first is TP53). Subsequent Sanger sequencing of matrix-remodeling associated 5 in an additional sample set consisting of 52 paired tumor-normal DNA samples revealed that 15% of Chinese NSCLCs contained somatic mutations in matrix-remodeling associated 5. These findings, together with the results from pathway analysis, strongly indicate that altered extracellular matrix-remodeling may be involved in the etiology of NSCLC.

AB - Lung cancer has become the top killer among malignant tumors in China and is significantly associated with somatic genetic alterations. We performed exome sequencing of 14 non-small cell lung carcinomas (NSCLCs) with matched adjacent normal lung tissues extracted from Chinese patients. In addition to the lung cancer-related genes (TP53, EGFR, KRAS, PIK3CA, and ROS1), this study revealed "novel" genes not previously implicated in NSCLC. Especially, matrix-remodeling associated 5 was the second most frequently mutated gene in NSCLC (first is TP53). Subsequent Sanger sequencing of matrix-remodeling associated 5 in an additional sample set consisting of 52 paired tumor-normal DNA samples revealed that 15% of Chinese NSCLCs contained somatic mutations in matrix-remodeling associated 5. These findings, together with the results from pathway analysis, strongly indicate that altered extracellular matrix-remodeling may be involved in the etiology of NSCLC.

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U2 - 10.1093/carcin/bgs210

DO - 10.1093/carcin/bgs210

M3 - Article

C2 - 22696596

AN - SCOPUS:84865569656

SN - 0143-3334

VL - 33

SP - 1797

EP - 1805

JO - Carcinogenesis

JF - Carcinogenesis

IS - 9

ER -

Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients

Abstract

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