EXPLICIT STABILIZED MULTIRATE METHODS FOR THE MONODOMAIN MODEL IN CARDIAC ELECTROPHYSIOLOGY

Giacomo Rosilho de Souza*, Marcus J. Grote, Simone Pezzuto, Rolf Krause

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Fully explicit stabilized multirate (mRKC) methods are well-suited for the numerical solution of large multiscale systems of stiff ordinary differential equations thanks to their improved stability properties. To demonstrate their efficiency for the numerical solution of stiff, multiscale, nonlinear parabolic PDE’s, we apply mRKC methods to the monodomain equation from cardiac electrophysiology. In doing so, we propose an improved version, specifically tailored to the monodomain model, which leads to the explicit exponential multirate stabilized (emRKC) method. Several numerical experiments are conducted to evaluate the efficiency of both mRKC and emRKC, while taking into account different finite element meshes (structured and unstructured) and realistic ionic models. The new emRKC method typically outperforms a standard implicit-explicit baseline method for cardiac electrophysiology. Code profiling and strong scalability results further demonstrate that emRKC is faster and inherently parallel without sacrificing accuracy.

Original languageEnglish (US)
Pages (from-to)2225-2254
Number of pages30
JournalESAIM: Mathematical Modelling and Numerical Analysis
Volume58
Issue number6
DOIs
StatePublished - Nov 1 2024

Keywords

  • electrophysiology
  • ionic model
  • local time-stepping
  • monodomain model
  • Multirate explicit stabilized methods
  • Rush–Larsen

ASJC Scopus subject areas

  • Analysis
  • Numerical Analysis
  • Modeling and Simulation
  • Computational Mathematics
  • Applied Mathematics

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