Expression of Fgf19 in the developing chick eye

Javier Francisco-Morcillo*, Hortensia Sánchez-Calderón, Yasuhiko Kawakami, Juan Carlos Izpisúa Belmonte, Matías Hidalgo-Sánchez, Gervasio Martín-Partido

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Fibroblast growth factor 19 (FGF19) is a new member of the FGF family of growth factors. Here, we describe the localization of Fgf19 mRNA in the developing chick retina and lens in stages from the Hamburger and Hamilton stage 15 (HH15) to postnatal day 30 (P30). Fgf19 was expressed in a transient manner in postmitotic neuroblasts during the migration from the ventricular surface to their final location. Moreover, from HH31 (embryonic day 7, E7) on, a subset of lined up Fgf19 expressing cells was distributed in the outer region of the presumptive INL. These cells were Pax6 immunoreactive horizontal cells. During the last third of embryogenesis, Fgf19 expression in the retina was progressively down-regulated and was not detected at P30. Also, it was transiently expressed in the equatorial region of the lens.

Original languageEnglish (US)
Pages (from-to)104-109
Number of pages6
JournalDevelopmental Brain Research
Issue number1
StatePublished - Apr 21 2005
Externally publishedYes


  • Chick embryo
  • Fgf19
  • Gradients of differentiation
  • Neurogenesis
  • Retinal development
  • Retinal neuroblasts

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology


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