Expression of Fgf19 in the developing chick eye

Javier Francisco-Morcillo; Hortensia Sánchez-Calderón; Yasuhiko Kawakami; Juan Carlos Izpisúa Belmonte; Matías Hidalgo-Sánchez; Gervasio Martín-Partido

doi:10.1016/j.devbrainres.2004.12.011

Expression of Fgf19 in the developing chick eye

Javier Francisco-Morcillo^*, Hortensia Sánchez-Calderón, Yasuhiko Kawakami, Juan Carlos Izpisúa Belmonte, Matías Hidalgo-Sánchez, Gervasio Martín-Partido

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Fibroblast growth factor 19 (FGF19) is a new member of the FGF family of growth factors. Here, we describe the localization of Fgf19 mRNA in the developing chick retina and lens in stages from the Hamburger and Hamilton stage 15 (HH15) to postnatal day 30 (P30). Fgf19 was expressed in a transient manner in postmitotic neuroblasts during the migration from the ventricular surface to their final location. Moreover, from HH31 (embryonic day 7, E7) on, a subset of lined up Fgf19 expressing cells was distributed in the outer region of the presumptive INL. These cells were Pax6 immunoreactive horizontal cells. During the last third of embryogenesis, Fgf19 expression in the retina was progressively down-regulated and was not detected at P30. Also, it was transiently expressed in the equatorial region of the lens.

Original language	English (US)
Pages (from-to)	104-109
Number of pages	6
Journal	Developmental Brain Research
Volume	156
Issue number	1
DOIs	https://doi.org/10.1016/j.devbrainres.2004.12.011
State	Published - Apr 21 2005
Externally published	Yes

Keywords

Chick embryo
Fgf19
Gradients of differentiation
Neurogenesis
Retinal development
Retinal neuroblasts

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/j.devbrainres.2004.12.011

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title = "Expression of Fgf19 in the developing chick eye",

abstract = "Fibroblast growth factor 19 (FGF19) is a new member of the FGF family of growth factors. Here, we describe the localization of Fgf19 mRNA in the developing chick retina and lens in stages from the Hamburger and Hamilton stage 15 (HH15) to postnatal day 30 (P30). Fgf19 was expressed in a transient manner in postmitotic neuroblasts during the migration from the ventricular surface to their final location. Moreover, from HH31 (embryonic day 7, E7) on, a subset of lined up Fgf19 expressing cells was distributed in the outer region of the presumptive INL. These cells were Pax6 immunoreactive horizontal cells. During the last third of embryogenesis, Fgf19 expression in the retina was progressively down-regulated and was not detected at P30. Also, it was transiently expressed in the equatorial region of the lens.",

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AU - Francisco-Morcillo, Javier

AU - Sánchez-Calderón, Hortensia

AU - Kawakami, Yasuhiko

AU - Belmonte, Juan Carlos Izpisúa

AU - Hidalgo-Sánchez, Matías

AU - Martín-Partido, Gervasio

PY - 2005/4/21

Y1 - 2005/4/21

N2 - Fibroblast growth factor 19 (FGF19) is a new member of the FGF family of growth factors. Here, we describe the localization of Fgf19 mRNA in the developing chick retina and lens in stages from the Hamburger and Hamilton stage 15 (HH15) to postnatal day 30 (P30). Fgf19 was expressed in a transient manner in postmitotic neuroblasts during the migration from the ventricular surface to their final location. Moreover, from HH31 (embryonic day 7, E7) on, a subset of lined up Fgf19 expressing cells was distributed in the outer region of the presumptive INL. These cells were Pax6 immunoreactive horizontal cells. During the last third of embryogenesis, Fgf19 expression in the retina was progressively down-regulated and was not detected at P30. Also, it was transiently expressed in the equatorial region of the lens.

AB - Fibroblast growth factor 19 (FGF19) is a new member of the FGF family of growth factors. Here, we describe the localization of Fgf19 mRNA in the developing chick retina and lens in stages from the Hamburger and Hamilton stage 15 (HH15) to postnatal day 30 (P30). Fgf19 was expressed in a transient manner in postmitotic neuroblasts during the migration from the ventricular surface to their final location. Moreover, from HH31 (embryonic day 7, E7) on, a subset of lined up Fgf19 expressing cells was distributed in the outer region of the presumptive INL. These cells were Pax6 immunoreactive horizontal cells. During the last third of embryogenesis, Fgf19 expression in the retina was progressively down-regulated and was not detected at P30. Also, it was transiently expressed in the equatorial region of the lens.

KW - Chick embryo

KW - Fgf19

KW - Gradients of differentiation

KW - Neurogenesis

KW - Retinal development

KW - Retinal neuroblasts

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JF - Developmental Brain Research

IS - 1

ER -

Expression of Fgf19 in the developing chick eye

Abstract

Keywords

ASJC Scopus subject areas

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