Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence cervical cancer development

Lanwei Guo, Juan Wen, Jing Han, Jie Jiang, Shuanghua Xie, Xiaoshuang Feng, Baojun Wei, Juncheng Dai, Kai Zhang, Jun Qi, Hongxia Ma, Jufang Shi, Jiansong Ren, Yue Zhang, Min Dai, Zhibin Hu, Ni Li

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Zinc ribbon domain containing 1 (ZNRD1) may play integral roles in immune response against HPV infection and cervical cancer. Its antisense transcript, ZNRD1-AS1, is an important regulator of ZNRD1. By bioinformatics analyses, we identified that several single nucleotide polymorphisms (SNPs) in ZNRD1-AS1 may be expression quantitative trait loci (eQTLs) for ZNRD1. So we hypothesized that these eQTLs SNPs in ZNRD1-AS1 may influence the susceptibility of cervical cancer through influencing ZNRD1 expression. We designed a population-based case-control study containing 1486 cervical cancer patients and 1536 controls to test the associations of three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and rs9261204) in ZNRD1-AS1 with the risk of cervical cancer. Logistic regression analyses in additive genetic model showed that all the three eQTLs SNPs decreased the risk of cervical cancer. Compared with those carrying "0" variant allele, subjects carrying "1-6" variant alleles had a 20% decreased risk of cervical cancer. Moreover, the haplotype containing variant alleles of these three SNPs significantly decreased the risk of cervical cancer when compared with the most frequent haplotype. In conclusion, ZNRD1 eQTLs SNPs in ZNRD1-AS1 could have a predisposition for the development of cervical cancer.
Original languageEnglish (US)
Pages (from-to)2301-2307
Number of pages7
JournalAmerican Journal of Cancer Research
Issue number7
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence cervical cancer development'. Together they form a unique fingerprint.

Cite this