Fabrication and Characterization of Porous Microneedles for Enhanced Fluid Injection and Suction: A Two-Photon Polymerization Approach

Esraa Fakeih; Andres A. Aguirre-Pablo; Sigurdur T Thoroddsen; Khaled N. Salama

doi:10.1002/adem.202300161

Fabrication and Characterization of Porous Microneedles for Enhanced Fluid Injection and Suction: A Two-Photon Polymerization Approach

Esraa Fakeih, Andres A. Aguirre-Pablo, Sigurdur T Thoroddsen, Khaled N. Salama

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Porous Microneedles (MNs) offer broad advantages such as fluid capture and filtration. Compared to hollow MNs, fluid injection through porous MNs causes a broader diffusion spread. In this paper, we fabricated and compared three MN designs with a constant pore size and controlled pore locations, using two-photon polymerization (2PP), by examining factors such as diffusion spread, mixing capabilities, and mechanical resilience. Results show that the porous MN can cover 16 times the injection area than that of the hollow MN. Porous MNs also showed good mixing capabilities with two fluids. Mechanical compression results revealed that one porous MN could withstand a load of 0.6 N.

Original language	English (US)
Journal	Advanced Engineering Materials
DOIs	https://doi.org/10.1002/adem.202300161
State	Published - Jun 29 2023

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics

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10.1002/adem.202300161

https://repository.kaust.edu.sa/bitstream/10754/692768/1/Adv%20Eng%20Mater%20-%202023%20-%20Fakeih%20-%20Fabrication%20and%20Characterization%20of%20Porous%20Microneedles%20for%20Enhanced%20Fluid%20Injection%20and.pdf

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title = "Fabrication and Characterization of Porous Microneedles for Enhanced Fluid Injection and Suction: A Two-Photon Polymerization Approach",

abstract = "Porous Microneedles (MNs) offer broad advantages such as fluid capture and filtration. Compared to hollow MNs, fluid injection through porous MNs causes a broader diffusion spread. In this paper, we fabricated and compared three MN designs with a constant pore size and controlled pore locations, using two-photon polymerization (2PP), by examining factors such as diffusion spread, mixing capabilities, and mechanical resilience. Results show that the porous MN can cover 16 times the injection area than that of the hollow MN. Porous MNs also showed good mixing capabilities with two fluids. Mechanical compression results revealed that one porous MN could withstand a load of 0.6 N.",

author = "Esraa Fakeih and Aguirre-Pablo, {Andres A.} and Thoroddsen, {Sigurdur T} and Salama, {Khaled N.}",

note = "KAUST Repository Item: Exported on 2023-07-04 Acknowledgements: This research was supported by King Abdullah University of Science and Technology.",

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doi = "10.1002/adem.202300161",

language = "English (US)",

journal = "Advanced Engineering Materials",

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TY - JOUR

T1 - Fabrication and Characterization of Porous Microneedles for Enhanced Fluid Injection and Suction: A Two-Photon Polymerization Approach

AU - Fakeih, Esraa

AU - Aguirre-Pablo, Andres A.

AU - Thoroddsen, Sigurdur T

AU - Salama, Khaled N.

N1 - KAUST Repository Item: Exported on 2023-07-04 Acknowledgements: This research was supported by King Abdullah University of Science and Technology.

PY - 2023/6/29

Y1 - 2023/6/29

N2 - Porous Microneedles (MNs) offer broad advantages such as fluid capture and filtration. Compared to hollow MNs, fluid injection through porous MNs causes a broader diffusion spread. In this paper, we fabricated and compared three MN designs with a constant pore size and controlled pore locations, using two-photon polymerization (2PP), by examining factors such as diffusion spread, mixing capabilities, and mechanical resilience. Results show that the porous MN can cover 16 times the injection area than that of the hollow MN. Porous MNs also showed good mixing capabilities with two fluids. Mechanical compression results revealed that one porous MN could withstand a load of 0.6 N.

AB - Porous Microneedles (MNs) offer broad advantages such as fluid capture and filtration. Compared to hollow MNs, fluid injection through porous MNs causes a broader diffusion spread. In this paper, we fabricated and compared three MN designs with a constant pore size and controlled pore locations, using two-photon polymerization (2PP), by examining factors such as diffusion spread, mixing capabilities, and mechanical resilience. Results show that the porous MN can cover 16 times the injection area than that of the hollow MN. Porous MNs also showed good mixing capabilities with two fluids. Mechanical compression results revealed that one porous MN could withstand a load of 0.6 N.

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UR - https://onlinelibrary.wiley.com/doi/10.1002/adem.202300161

U2 - 10.1002/adem.202300161

DO - 10.1002/adem.202300161

M3 - Article

SN - 1438-1656

JO - Advanced Engineering Materials

JF - Advanced Engineering Materials

ER -

Fabrication and Characterization of Porous Microneedles for Enhanced Fluid Injection and Suction: A Two-Photon Polymerization Approach

Abstract

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