The design and implementation of interdigital sensors in the sensing world have been pivotal in the last few decades. Due to the advantages imparted by these designs, researchers all over the world have practiced developing prototypes based on them. The variation in the physical and material specificities of the interdigital sensors varies with their individual applications. In order to develop a range of sensing prototypes for biomedical, industrial and environmental applications, the optimization of the fabrication of these interdigitated electrodes has been done over the years. This chapter highlights some of the research works done on their design, development and implementation, based on a range of fabrication processes. Some of the issues faced by each of these fabrication techniques, as well as the formed prototypes, have also been discussed in the chapter. Finally, some of the possible remedies to address the existing issues have been elucidated, along with a brief market survey that has been mentioned at the end of the chapter.