TY - JOUR
T1 - Fabrication of thulium metal–organic frameworks based smartphone sensor towards arsenical feed additive drug detection: Applicable in food safety analysis
AU - Chinnapaiyan, Sathishkumar
AU - Rajaji, Umamaheswari
AU - Chen, Shen Ming
AU - Liu, Ting Yu
AU - De Oliveira Filho, Jose
AU - Chang, Yo Shiuan
N1 - KAUST Repository Item: Exported on 2021-11-16
Acknowledgements: The authors gratefully acknowledge the financial support of the Ministry of Science and Technology, MOST 110-2221-E-131-009, Taiwan and Research Centre for Intelligent Medical Devices of Ming Chi University of Technology, Taiwan and King Abdullah University of Science and Technology (KAUST), Saudi Arabia.
PY - 2021/10/26
Y1 - 2021/10/26
N2 - A portable sensor is needed for the quick screening of additives in food samples, to ensure food safety. The consumption of roxarsone (ROX) contaminated meat increases arsenic toxicity, risk of cancer and neurodegenerative diseases. In this research work, we report the synthesis of thulium (III)-benzene 1,3,5-tricarboxylic acid-based metal-organic framework (Tm-BTC MOF) and its use as an excellent electrocatalyst for the determination of ROX at point-of-care. A hydrothermal procedure was developed for the synthesis of Tm-BTC MOF using a single polarity solvent. A Tm-BTC MOF modified electrode was fabricated and its electrocatalytic sensing ability towards ROX was explored. Three kinds of special chemical interactions form a special affinity between ROX and Tm-BTC MOF. In association with differential pulse voltammetry, the Tm-BTC MOF/GCE showed a low detection limit of 100 pM. The Tm-BTC MOF modified electrode was integrated into a portable sensing device via coupling it with a miniaturized potentiostat (KAUSTat) operated wirelessly by a smartphone. The developed smartphone-based sensor was successful in measuring ROX not only in lab samples but also in real (spiked) food samples. The method can be suitable for on-site testing of food quality and safety in resource-limited settings.
AB - A portable sensor is needed for the quick screening of additives in food samples, to ensure food safety. The consumption of roxarsone (ROX) contaminated meat increases arsenic toxicity, risk of cancer and neurodegenerative diseases. In this research work, we report the synthesis of thulium (III)-benzene 1,3,5-tricarboxylic acid-based metal-organic framework (Tm-BTC MOF) and its use as an excellent electrocatalyst for the determination of ROX at point-of-care. A hydrothermal procedure was developed for the synthesis of Tm-BTC MOF using a single polarity solvent. A Tm-BTC MOF modified electrode was fabricated and its electrocatalytic sensing ability towards ROX was explored. Three kinds of special chemical interactions form a special affinity between ROX and Tm-BTC MOF. In association with differential pulse voltammetry, the Tm-BTC MOF/GCE showed a low detection limit of 100 pM. The Tm-BTC MOF modified electrode was integrated into a portable sensing device via coupling it with a miniaturized potentiostat (KAUSTat) operated wirelessly by a smartphone. The developed smartphone-based sensor was successful in measuring ROX not only in lab samples but also in real (spiked) food samples. The method can be suitable for on-site testing of food quality and safety in resource-limited settings.
UR - http://hdl.handle.net/10754/673391
UR - https://linkinghub.elsevier.com/retrieve/pii/S0013468621017734
UR - http://www.scopus.com/inward/record.url?scp=85118494032&partnerID=8YFLogxK
U2 - 10.1016/j.electacta.2021.139487
DO - 10.1016/j.electacta.2021.139487
M3 - Article
SN - 0013-4686
VL - 401
SP - 139487
JO - Electrochimica Acta
JF - Electrochimica Acta
ER -