Field approach to three-dimensional gene expression pattern characterization

L. Da F. Costa*, B. A.N. Traveņolo, A. Azeredo, M. E. Beletti, G. B. Müller, D. Rasskin-Gutman, G. Sternik, M. Ibañes, J. C. Izpisúa-Belmonte

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We present a vector field method for obtaining the spatial organization of three-dimensional patterns of gene expression based on gradients and lines of force obtained by numerical integration. The convergence of these lines of force in local maxima are centers of gene expression, providing a natural and powerful framework to characterize the organization and dynamics of biological structures. We apply this methodology to analyze the expression pattern of the enhanced green fluorescent protein (EGFP) driven by the promoter of light chain myosin II during zebrafish heart formation.

Original languageEnglish (US)
Article number143901
Pages (from-to)1-3
Number of pages3
JournalApplied Physics Letters
Issue number14
StatePublished - Apr 4 2005
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)


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