Abstract
The first catalytic enantioselective synthesis of benzodiazepinones employing an efficient hydrogenation protocol has been developed. The corresponding products are obtained in good yields, with excellent enantioselectivities and broad functional group tolerance. In addition, a one-pot procedure involving in situ generation of benzodiazepin-2-ones followed by asymmetric reduction is presented.
Original language | English (US) |
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Pages (from-to) | 2629-2634 |
Number of pages | 6 |
Journal | Advanced Synthesis and Catalysis |
Volume | 352 |
Issue number | 14-15 |
DOIs | |
State | Published - Oct 4 2010 |
Externally published | Yes |
Keywords
- Brønsted acids
- Hantzsch dihydropyridines
- asymmetric hydrogenation
- enantioselective reduction
- organocatalysis
- β-amino acids
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry