Fluorescence resonance energy transfer enhanced photothermal and photodynamic antibacterial therapy post a single injection

Lei Xue, Qing Shen, Tian Zhang, Yibin Fan, Xiaogang Xu, Jinjun Shao*, Dongliang Yang, Wenli Zhao, Xiaochen Dong*, Xiaozhou Mou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Refractory MRSA infections seriously threaten human health, which compromises antibiotic efficacy. Although phototherapy has exhibited great feasibility in the fight against drug-resistant pathogens, a single-modal therapeutic agent without targeted performance has resulted in low drug utilization and obvious side effects. Herein, near-infrared (NIR) light-triggered theranostic nanoparticles (NDIA@PEG-Ce6/B NPs) were prepared by employing naphthalene diimide derivative NDIA as a photothermal agent, PEGylated chlorin e6 (PEG-Ce6) as a photosensitizer and PEGylated phenylboronic acid (PEG-B) as a bacteria-targeting agent. Upon laser irradiation, the singlet oxygen produced by Ce6 can efficiently kill bacteria through photodynamic therapy. Moreover, the fluorescence emission of Ce6 can be absorbed by the photothermal agent NDIA with a fluorescence resonance energy transfer (FRET) efficiency of 78% to reinforce the photothermal effect of NDIA, and the photothermal conversion efficiency of NDIA@PEG-Ce6/B NPs was up to 49.7%. In vitro and in vivo antibacterial experiments indicated that NDIA@PEG-Ce6/B NPs could targeted assembly and effectively destroy multidrug-resistant bacteria through synergistic photothermal and photodynamic therapy with 99.999% antibacterial efficacy under NIR light illumination. The study provides a nanosystem for the antibacterial treatment of synergistic photodynamic and photothermal therapy for subcutaneous abscesses, as well as a novel FRET strategy for further design of light-triggered antibacterial nanoplatforms.

Original languageEnglish (US)
Pages (from-to)6061-6070
Number of pages10
JournalMaterials Chemistry Frontiers
Volume5
Issue number16
DOIs
StatePublished - Aug 21 2021

ASJC Scopus subject areas

  • General Materials Science
  • Materials Chemistry

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