Forskolin but not isoprenaline increases sodium current from frog cardiac myocytes

R. Bonvallet; F. Lemtiri-Chlieh; O. Rougier

doi:10.1113/expphysiol.1990.sp003466

Forskolin but not isoprenaline increases sodium current from frog cardiac myocytes

R. Bonvallet^*, F. Lemtiri-Chlieh, O. Rougier

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The effect of forskolin on sodium current (INa) was studied in enzymatically dispersed frog atrial myocytes. The single pipette patch‐clamp technique was used, with a low external sodium concentration. Forskolin (0.5 microM) increased INa at all potentials between ‐50 and +30 mV. The forskolin‐induced increase of INa was mimicked by 1,9‐dideoxyforskolin (0.5 microM) but not by isoprenaline (2 microM). These results suggest that forskolin can modulate INa through a mechanism that does not involve the production of cyclic AMP.

Original language	English (US)
Pages (from-to)	843-846
Number of pages	4
Journal	Experimental Physiology
Volume	75
Issue number	6
DOIs	https://doi.org/10.1113/expphysiol.1990.sp003466
State	Published - Nov 1 1990
Externally published	Yes

ASJC Scopus subject areas

Physiology (medical)
Nutrition and Dietetics
Physiology

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10.1113/expphysiol.1990.sp003466

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title = "Forskolin but not isoprenaline increases sodium current from frog cardiac myocytes",

abstract = "The effect of forskolin on sodium current (INa) was studied in enzymatically dispersed frog atrial myocytes. The single pipette patch‐clamp technique was used, with a low external sodium concentration. Forskolin (0.5 microM) increased INa at all potentials between ‐50 and +30 mV. The forskolin‐induced increase of INa was mimicked by 1,9‐dideoxyforskolin (0.5 microM) but not by isoprenaline (2 microM). These results suggest that forskolin can modulate INa through a mechanism that does not involve the production of cyclic AMP.",

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AU - Bonvallet, R.

AU - Lemtiri-Chlieh, F.

AU - Rougier, O.

PY - 1990/11/1

Y1 - 1990/11/1

N2 - The effect of forskolin on sodium current (INa) was studied in enzymatically dispersed frog atrial myocytes. The single pipette patch‐clamp technique was used, with a low external sodium concentration. Forskolin (0.5 microM) increased INa at all potentials between ‐50 and +30 mV. The forskolin‐induced increase of INa was mimicked by 1,9‐dideoxyforskolin (0.5 microM) but not by isoprenaline (2 microM). These results suggest that forskolin can modulate INa through a mechanism that does not involve the production of cyclic AMP.

AB - The effect of forskolin on sodium current (INa) was studied in enzymatically dispersed frog atrial myocytes. The single pipette patch‐clamp technique was used, with a low external sodium concentration. Forskolin (0.5 microM) increased INa at all potentials between ‐50 and +30 mV. The forskolin‐induced increase of INa was mimicked by 1,9‐dideoxyforskolin (0.5 microM) but not by isoprenaline (2 microM). These results suggest that forskolin can modulate INa through a mechanism that does not involve the production of cyclic AMP.

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JO - Experimental Physiology

JF - Experimental Physiology

IS - 6

ER -

Forskolin but not isoprenaline increases sodium current from frog cardiac myocytes

Abstract

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