Abstract
Four new polycyclic antibiotics, citreamicin ? A (1), citreamicin ? B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin ? A (1), citreamicin ? B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 ?g/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. 2012 by the authors; licensee MDPI.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2571-2583 |
| Number of pages | 13 |
| Journal | Marine Drugs |
| Volume | 10 |
| Issue number | 12 |
| DOIs | |
| State | Published - Nov 20 2012 |
ASJC Scopus subject areas
- Drug Discovery
Access to Document
Other files and links
Fingerprint
Dive into the research topics of 'Four new antibacterial xanthones from the marine-derived actinomycetes Streptomyces caelestis'. Together they form a unique fingerprint.Datasets
-
CCDC 1865054: Experimental Crystal Structure Determination : 4,6,7,17-tetrahydroxy-14-(hydroxymethyl)-3-methoxy-11a,14-dimethyl-8,9,11,11a-tetrahydro[1]benzopyrano[3',2':7,8]naphtho[2,1-g][1,3]oxazolo[3,2-b]isoquinoline-5,13,16(14H)-trione monohydrate
Liu, L.-L. (Creator), Xu, Y. (Creator), Han, Z. (Creator), Li, Y.-X. (Creator), Lu, L. (Creator), Lai, P.-Y. (Creator), Zhong, J.-L. (Creator), Guo, X. (Creator), Zhang, X. (Creator), Qian, P.-Y. (Creator), Liu, L.-L. (Creator), Xu, Y. (Creator), Han, Z. (Creator), Li, Y.-X. (Creator), Lu, L. (Creator), Lai, P.-Y. (Creator), Zhong, J.-L. (Creator) & Qian, P.-Y. (Creator), Cambridge Crystallographic Data Centre, Sep 1 2018
DOI: 10.5517/ccdc.csd.cc20lr1f, http://hdl.handle.net/10754/663498
Dataset