Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos

Lise Zakin; Bruno Reversade; Bérangère Virlon; Christophe Rusniok; Philippe Glaser; Jean Marc Elalouf; Philippe Brûlet

doi:10.1073/pnas.011513398

Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos

Lise Zakin, Bruno Reversade, Bérangère Virlon, Christophe Rusniok, Philippe Glaser, Jean Marc Elalouf, Philippe Brûlet

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2-/- 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation.

Original language	English (US)
Pages (from-to)	14388-14393
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	97
Issue number	26
DOIs	https://doi.org/10.1073/pnas.011513398
State	Published - Dec 19 2000
Externally published	Yes

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abstract = "The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2-/- 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation.",

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AU - Zakin, Lise

AU - Reversade, Bruno

AU - Virlon, Bérangère

AU - Rusniok, Christophe

AU - Glaser, Philippe

AU - Elalouf, Jean Marc

AU - Brûlet, Philippe

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AB - The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2-/- 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation.

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ER -

Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos

Abstract

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