Gene Expression Signatures Diagnose Influenza and Other Symptomatic Respiratory Viral Infections in Humans

Aimee K. Zaas; Minhua Chen; Jay Varkey; Timothy Veldman; Alfred O. Hero; Joseph Lucas; Yongsheng Huang; Ronald Turner; Anthony Gilbert; Robert Lambkin-Williams; N. Christine Øien; Bradly Nicholson; Stephen Kingsmore; Lawrence Carin; Christopher W. Woods; Geoffrey S. Ginsburg

doi:10.1016/j.chom.2009.07.006

Gene Expression Signatures Diagnose Influenza and Other Symptomatic Respiratory Viral Infections in Humans

Aimee K. Zaas, Minhua Chen, Jay Varkey, Timothy Veldman, Alfred O. Hero, Joseph Lucas, Yongsheng Huang, Ronald Turner, Anthony Gilbert, Robert Lambkin-Williams, N. Christine Øien, Bradly Nicholson, Stephen Kingsmore, Lawrence Carin, Christopher W. Woods, Geoffrey S. Ginsburg

Research output: Contribution to journal › Article › peer-review

341 Scopus citations

Abstract

Acute respiratory infections (ARIs) are a common reason for seeking medical attention, and the threat of pandemic influenza will likely add to these numbers. Using human viral challenge studies with live rhinovirus, respiratory syncytial virus, and influenza A, we developed peripheral blood gene expression signatures that distinguish individuals with symptomatic ARIs from uninfected individuals with >95% accuracy. We validated this "acute respiratory viral" signature-encompassing genes with a known role in host defense against viral infections-across each viral challenge. We also validated the signature in an independently acquired data set for influenza A and classified infected individuals from healthy controls with 100% accuracy. In the same data set, we could also distinguish viral from bacterial ARIs (93% accuracy). These results demonstrate that ARIs induce changes in human peripheral blood gene expression that can be used to diagnose a viral etiology of respiratory infection and triage symptomatic individuals. © 2009 Elsevier Inc. All rights reserved.

Original language	English (US)
Pages (from-to)	207-217
Number of pages	11
Journal	Cell Host and Microbe
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2009.07.006
State	Published - Sep 17 2009
Externally published	Yes

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Zaas, A. K., Chen, M., Varkey, J., Veldman, T., Hero, A. O., Lucas, J., Huang, Y., Turner, R., Gilbert, A., Lambkin-Williams, R., Øien, N. C., Nicholson, B., Kingsmore, S., Carin, L., Woods, C. W., & Ginsburg, G. S. (2009). Gene Expression Signatures Diagnose Influenza and Other Symptomatic Respiratory Viral Infections in Humans. Cell Host and Microbe, 6(3), 207-217. https://doi.org/10.1016/j.chom.2009.07.006

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title = "Gene Expression Signatures Diagnose Influenza and Other Symptomatic Respiratory Viral Infections in Humans",

abstract = "Acute respiratory infections (ARIs) are a common reason for seeking medical attention, and the threat of pandemic influenza will likely add to these numbers. Using human viral challenge studies with live rhinovirus, respiratory syncytial virus, and influenza A, we developed peripheral blood gene expression signatures that distinguish individuals with symptomatic ARIs from uninfected individuals with >95% accuracy. We validated this {"}acute respiratory viral{"} signature-encompassing genes with a known role in host defense against viral infections-across each viral challenge. We also validated the signature in an independently acquired data set for influenza A and classified infected individuals from healthy controls with 100% accuracy. In the same data set, we could also distinguish viral from bacterial ARIs (93% accuracy). These results demonstrate that ARIs induce changes in human peripheral blood gene expression that can be used to diagnose a viral etiology of respiratory infection and triage symptomatic individuals. {\textcopyright} 2009 Elsevier Inc. All rights reserved.",

author = "Zaas, {Aimee K.} and Minhua Chen and Jay Varkey and Timothy Veldman and Hero, {Alfred O.} and Joseph Lucas and Yongsheng Huang and Ronald Turner and Anthony Gilbert and Robert Lambkin-Williams and {\O}ien, {N. Christine} and Bradly Nicholson and Stephen Kingsmore and Lawrence Carin and Woods, {Christopher W.} and Ginsburg, {Geoffrey S.}",

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Zaas, AK, Chen, M, Varkey, J, Veldman, T, Hero, AO, Lucas, J, Huang, Y, Turner, R, Gilbert, A, Lambkin-Williams, R, Øien, NC, Nicholson, B, Kingsmore, S, Carin, L, Woods, CW & Ginsburg, GS 2009, 'Gene Expression Signatures Diagnose Influenza and Other Symptomatic Respiratory Viral Infections in Humans', Cell Host and Microbe, vol. 6, no. 3, pp. 207-217. https://doi.org/10.1016/j.chom.2009.07.006

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T1 - Gene Expression Signatures Diagnose Influenza and Other Symptomatic Respiratory Viral Infections in Humans

AU - Zaas, Aimee K.

AU - Chen, Minhua

AU - Varkey, Jay

AU - Veldman, Timothy

AU - Hero, Alfred O.

AU - Lucas, Joseph

AU - Huang, Yongsheng

AU - Turner, Ronald

AU - Gilbert, Anthony

AU - Lambkin-Williams, Robert

AU - Øien, N. Christine

AU - Nicholson, Bradly

AU - Kingsmore, Stephen

AU - Carin, Lawrence

AU - Woods, Christopher W.

AU - Ginsburg, Geoffrey S.

N1 - Generated from Scopus record by KAUST IRTS on 2021-02-09

PY - 2009/9/17

Y1 - 2009/9/17

N2 - Acute respiratory infections (ARIs) are a common reason for seeking medical attention, and the threat of pandemic influenza will likely add to these numbers. Using human viral challenge studies with live rhinovirus, respiratory syncytial virus, and influenza A, we developed peripheral blood gene expression signatures that distinguish individuals with symptomatic ARIs from uninfected individuals with >95% accuracy. We validated this "acute respiratory viral" signature-encompassing genes with a known role in host defense against viral infections-across each viral challenge. We also validated the signature in an independently acquired data set for influenza A and classified infected individuals from healthy controls with 100% accuracy. In the same data set, we could also distinguish viral from bacterial ARIs (93% accuracy). These results demonstrate that ARIs induce changes in human peripheral blood gene expression that can be used to diagnose a viral etiology of respiratory infection and triage symptomatic individuals. © 2009 Elsevier Inc. All rights reserved.

AB - Acute respiratory infections (ARIs) are a common reason for seeking medical attention, and the threat of pandemic influenza will likely add to these numbers. Using human viral challenge studies with live rhinovirus, respiratory syncytial virus, and influenza A, we developed peripheral blood gene expression signatures that distinguish individuals with symptomatic ARIs from uninfected individuals with >95% accuracy. We validated this "acute respiratory viral" signature-encompassing genes with a known role in host defense against viral infections-across each viral challenge. We also validated the signature in an independently acquired data set for influenza A and classified infected individuals from healthy controls with 100% accuracy. In the same data set, we could also distinguish viral from bacterial ARIs (93% accuracy). These results demonstrate that ARIs induce changes in human peripheral blood gene expression that can be used to diagnose a viral etiology of respiratory infection and triage symptomatic individuals. © 2009 Elsevier Inc. All rights reserved.

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JO - Cell Host and Microbe

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Gene Expression Signatures Diagnose Influenza and Other Symptomatic Respiratory Viral Infections in Humans

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