Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes

Malcolm J. Gardner; Richard Bishop; Trushar Shah; Etienne P. De Villiers; Jane M. Carlton; Neil Hall; Qinghu Ren; Ian T. Paulsen; Arnab Pain; Matthew Berriman; Robert J.M. Wilson; Shigeharu Sato; Stuart A. Ralph; David J. Mann; Zikai Xiong; Shamira J. Shallom; Janice Weidman; Lingxia Jiang; Jeffery Lynn; Bruce Weaver; Azadeh Shoaibi; Alexander R. Domingo; Delia Wasawo; Jonathan Crabtree; Jennifer R. Wortman; Brian Haas; Samuel V. Angiuoli; Todd H. Creasy; Charles Lu; Bernard Suh; Joana C. Silva; Teresa R. Utterback; Tamara V. Feldblyum; Mihaela Pertea; Jonathan Allen; William C. Nierman; Evans L.N. Taracha; Steven L. Salzberg; Owen R. White; Henry A. Fitzhugh; Subhash Morzaria; J. Craig Venter; Claire M. Fraser; Vishvanath Nene

doi:10.1126/science.1110439

Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes

Malcolm J. Gardner^*, Richard Bishop, Trushar Shah, Etienne P. De Villiers, Jane M. Carlton, Neil Hall, Qinghu Ren, Ian T. Paulsen, Arnab Pain, Matthew Berriman, Robert J.M. Wilson, Shigeharu Sato, Stuart A. Ralph, David J. Mann, Zikai Xiong, Shamira J. Shallom, Janice Weidman, Lingxia Jiang, Jeffery Lynn, Bruce WeaverAzadeh Shoaibi, Alexander R. Domingo, Delia Wasawo, Jonathan Crabtree, Jennifer R. Wortman, Brian Haas, Samuel V. Angiuoli, Todd H. Creasy, Charles Lu, Bernard Suh, Joana C. Silva, Teresa R. Utterback, Tamara V. Feldblyum, Mihaela Pertea, Jonathan Allen, William C. Nierman, Evans L.N. Taracha, Steven L. Salzberg, Owen R. White, Henry A. Fitzhugh, Subhash Morzaria, J. Craig Venter, Claire M. Fraser, Vishvanath Nene

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

287 Scopus citations

Abstract

We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.

Original language	English (US)
Pages (from-to)	134-137
Number of pages	4
Journal	SCIENCE
Volume	309
Issue number	5731
DOIs	https://doi.org/10.1126/science.1110439
State	Published - Jul 1 2005
Externally published	Yes

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Gardner, M. J., Bishop, R., Shah, T., De Villiers, E. P., Carlton, J. M., Hall, N., Ren, Q., Paulsen, I. T., Pain, A., Berriman, M., Wilson, R. J. M., Sato, S., Ralph, S. A., Mann, D. J., Xiong, Z., Shallom, S. J., Weidman, J., Jiang, L., Lynn, J., ... Nene, V. (2005). Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes. SCIENCE, 309(5731), 134-137. https://doi.org/10.1126/science.1110439

@article{796d49af0e8943e19c946f8dd3f8e883,

title = "Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes",

abstract = "We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.",

author = "Gardner, {Malcolm J.} and Richard Bishop and Trushar Shah and {De Villiers}, {Etienne P.} and Carlton, {Jane M.} and Neil Hall and Qinghu Ren and Paulsen, {Ian T.} and Arnab Pain and Matthew Berriman and Wilson, {Robert J.M.} and Shigeharu Sato and Ralph, {Stuart A.} and Mann, {David J.} and Zikai Xiong and Shallom, {Shamira J.} and Janice Weidman and Lingxia Jiang and Jeffery Lynn and Bruce Weaver and Azadeh Shoaibi and Domingo, {Alexander R.} and Delia Wasawo and Jonathan Crabtree and Wortman, {Jennifer R.} and Brian Haas and Angiuoli, {Samuel V.} and Creasy, {Todd H.} and Charles Lu and Bernard Suh and Silva, {Joana C.} and Utterback, {Teresa R.} and Feldblyum, {Tamara V.} and Mihaela Pertea and Jonathan Allen and Nierman, {William C.} and Taracha, {Evans L.N.} and Salzberg, {Steven L.} and White, {Owen R.} and Fitzhugh, {Henry A.} and Subhash Morzaria and Venter, {J. Craig} and Fraser, {Claire M.} and Vishvanath Nene",

year = "2005",

month = jul,

day = "1",

doi = "10.1126/science.1110439",

language = "English (US)",

volume = "309",

pages = "134--137",

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Gardner, MJ, Bishop, R, Shah, T, De Villiers, EP, Carlton, JM, Hall, N, Ren, Q, Paulsen, IT, Pain, A, Berriman, M, Wilson, RJM, Sato, S, Ralph, SA, Mann, DJ, Xiong, Z, Shallom, SJ, Weidman, J, Jiang, L, Lynn, J, Weaver, B, Shoaibi, A, Domingo, AR, Wasawo, D, Crabtree, J, Wortman, JR, Haas, B, Angiuoli, SV, Creasy, TH, Lu, C, Suh, B, Silva, JC, Utterback, TR, Feldblyum, TV, Pertea, M, Allen, J, Nierman, WC, Taracha, ELN, Salzberg, SL, White, OR, Fitzhugh, HA, Morzaria, S, Venter, JC, Fraser, CM & Nene, V 2005, 'Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes', SCIENCE, vol. 309, no. 5731, pp. 134-137. https://doi.org/10.1126/science.1110439

TY - JOUR

T1 - Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes

AU - Gardner, Malcolm J.

AU - Bishop, Richard

AU - Shah, Trushar

AU - De Villiers, Etienne P.

AU - Carlton, Jane M.

AU - Hall, Neil

AU - Ren, Qinghu

AU - Paulsen, Ian T.

AU - Pain, Arnab

AU - Berriman, Matthew

AU - Wilson, Robert J.M.

AU - Sato, Shigeharu

AU - Ralph, Stuart A.

AU - Mann, David J.

AU - Xiong, Zikai

AU - Shallom, Shamira J.

AU - Weidman, Janice

AU - Jiang, Lingxia

AU - Lynn, Jeffery

AU - Weaver, Bruce

AU - Shoaibi, Azadeh

AU - Domingo, Alexander R.

AU - Wasawo, Delia

AU - Crabtree, Jonathan

AU - Wortman, Jennifer R.

AU - Haas, Brian

AU - Angiuoli, Samuel V.

AU - Creasy, Todd H.

AU - Lu, Charles

AU - Suh, Bernard

AU - Silva, Joana C.

AU - Utterback, Teresa R.

AU - Feldblyum, Tamara V.

AU - Pertea, Mihaela

AU - Allen, Jonathan

AU - Nierman, William C.

AU - Taracha, Evans L.N.

AU - Salzberg, Steven L.

AU - White, Owen R.

AU - Fitzhugh, Henry A.

AU - Morzaria, Subhash

AU - Venter, J. Craig

AU - Fraser, Claire M.

AU - Nene, Vishvanath

PY - 2005/7/1

Y1 - 2005/7/1

N2 - We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.

AB - We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.

UR - http://www.scopus.com/inward/record.url?scp=21644437935&partnerID=8YFLogxK

U2 - 10.1126/science.1110439

DO - 10.1126/science.1110439

M3 - Article

C2 - 15994558

AN - SCOPUS:21644437935

SN - 0036-8075

VL - 309

SP - 134

EP - 137

JO - SCIENCE

JF - SCIENCE

IS - 5731

ER -

Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes

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