Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens

Chih Hua Chao; Ju Chien Cheng; Théo P. Gonçalves; Kuo Wei Huang; Chi Chien Lin; Hui Chi Huang; Syh Yuan Hwang; Yang Chang Wu

doi:10.1038/s41598-018-33748-6

Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens

Chih Hua Chao^*, Ju Chien Cheng, Théo P. Gonçalves, Kuo Wei Huang, Chi Chien Lin, Hui Chi Huang, Syh Yuan Hwang, Yang Chang Wu

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.

Original language	English (US)
Article number	15417
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-33748-6
State	Published - Dec 1 2018

ASJC Scopus subject areas

General

Access to Document

10.1038/s41598-018-33748-6

Cite this

@article{14213e34a1b0420e9dd076b3e7f7dff9,

title = "Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens",

abstract = "Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.",

author = "Chao, {Chih Hua} and Cheng, {Ju Chien} and Gon{\c c}alves, {Th{\'e}o P.} and Huang, {Kuo Wei} and Lin, {Chi Chien} and Huang, {Hui Chi} and Hwang, {Syh Yuan} and Wu, {Yang Chang}",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",

year = "2018",

month = dec,

day = "1",

doi = "10.1038/s41598-018-33748-6",

language = "English (US)",

volume = "8",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens

AU - Chao, Chih Hua

AU - Cheng, Ju Chien

AU - Gonçalves, Théo P.

AU - Huang, Kuo Wei

AU - Lin, Chi Chien

AU - Huang, Hui Chi

AU - Hwang, Syh Yuan

AU - Wu, Yang Chang

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.

AB - Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.

UR - http://www.scopus.com/inward/record.url?scp=85055078694&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-33748-6

DO - 10.1038/s41598-018-33748-6

M3 - Article

C2 - 30337630

AN - SCOPUS:85055078694

SN - 2045-2322

VL - 8

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 15417

ER -

Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this