Abstract
Original language | English (US) |
---|---|
Pages (from-to) | 459-480 |
Number of pages | 22 |
Journal | The Lancet Neurology |
Volume | 18 |
Issue number | 5 |
DOIs | |
State | Published - May 1 2019 |
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In: The Lancet Neurology, Vol. 18, No. 5, 01.05.2019, p. 459-480.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
AU - Feigin, Valery L.
AU - Nichols, Emma
AU - Alam, Tahiya
AU - Bannick, Marlena S.
AU - Beghi, Ettore
AU - Blake, Natacha
AU - Culpepper, William J.
AU - Dorsey, E. Ray
AU - Elbaz, Alexis
AU - Ellenbogen, Richard G.
AU - Fisher, James L.
AU - Fitzmaurice, Christina
AU - Giussani, Giorgia
AU - Glennie, Linda
AU - James, Spencer L.
AU - Johnson, Catherine Owens
AU - Kassebaum, Nicholas J.
AU - Logroscino, Giancarlo
AU - Marin, Benoît
AU - Mountjoy-Venning, W. Cliff
AU - Nguyen, Minh
AU - Ofori-Asenso, Richard
AU - Patel, Anoop P.
AU - Piccininni, Marco
AU - Roth, Gregory A.
AU - Steiner, Timothy J.
AU - Stovner, Lars Jacob
AU - Szoeke, Cassandra E.I.
AU - Theadom, Alice
AU - Vollset, Stein Emil
AU - Wallin, Mitchell Taylor
AU - Wright, Claire
AU - Zunt, Joseph Raymond
AU - Abbasi, Nooshin
AU - Abd-Allah, Foad
AU - Abdelalim, Ahmed
AU - Abdollahpour, Ibrahim
AU - Aboyans, Victor
AU - Abraha, Haftom Niguse
AU - Acharya, Dilaram
AU - Adamu, Abdu A.
AU - Adebayo, Oladimeji M.
AU - Adeoye, Abiodun Moshood
AU - Adsuar, Jose C.
AU - Afarideh, Mohsen
AU - Agrawal, Sutapa
AU - Ahmadi, Alireza
AU - Ahmed, Muktar Beshir
AU - Aichour, Amani Nidhal
AU - Aichour, Ibtihel
AU - Aichour, Miloud Taki Eddine
AU - Akinyemi, Rufus Olusola
AU - Akseer, Nadia
AU - Al-Eyadhy, Ayman
AU - Al-Shahi Salman, Rustam
AU - Alahdab, Fares
AU - Alene, Kefyalew Addis
AU - Aljunid, Syed Mohamed
AU - Altirkawi, Khalid
AU - Alvis-Guzman, Nelson
AU - Anber, Nahla Hamed
AU - Antonio, Carl Abelardo T.
AU - Arabloo, Jalal
AU - Aremu, Olatunde
AU - Ärnlöv, Johan
AU - Asayesh, Hamid
AU - Asghar, Rana Jawad
AU - Atalay, Hagos Tasew
AU - Awasthi, Ashish
AU - Ayala Quintanilla, Beatriz Paulina
AU - Ayuk, Tambe B.
AU - Badawi, Alaa
AU - Banach, Maciej
AU - Banoub, Joseph Adel Mattar
AU - Barboza, Miguel A.
AU - Barker-Collo, Suzanne Lyn
AU - Bärnighausen, Till Winfried
AU - Baune, Bernhard T.
AU - Bedi, Neeraj
AU - Behzadifar, Masoud
AU - Behzadifar, Meysam
AU - Béjot, Yannick
AU - Bekele, Bayu Begashaw
AU - Belachew, Abate Bekele
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AU - Bensenor, Isabela M.
AU - Berhane, Adugnaw
AU - Beuran, Mircea
AU - Bhattacharyya, Krittika
AU - Bhutta, Zulfiqar A.
AU - Biadgo, Belete
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AU - Bililign, Nigus
AU - Bin Sayeed, Muhammad Shahdaat
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AU - Cantu-Brito, Carlos
AU - Car, Mate
AU - Cárdenas, Rosario
AU - Carrero, Juan J.
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AU - Castro, Franz
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AU - Hamidi, Samer
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AU - Haro, Josep Maria
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AU - Havmoeller, Rasmus
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AU - Hegazy, Mohamed I.
AU - Heidari, Behnam
AU - Henok, Andualem
AU - Heydarpour, Fatemeh
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AU - Hosseini, Seyed Mostafa
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AU - Irvani, Seyed Sina Naghibi
AU - Islam, Sheikh Mohammed Shariful
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AU - Javanbakht, Mehdi
AU - Jha, Ravi Prakash
AU - Jobanputra, Yash B.
AU - Jonas, Jost B.
AU - Józwiak, Jacek Jerzy
AU - Jürisson, Mikk
AU - Kahsay, Amaha
AU - Kalani, Rizwan
AU - Kalkonde, Yogeshwar
AU - Kamil, Teshome Abegaz
AU - Kanchan, Tanuj
AU - Karami, Manoochehr
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AU - Karimi, Narges
AU - Kasaeian, Amir
AU - Kassa, Tesfaye Dessale
AU - Kassa, Zemenu Yohannes
AU - Kaul, Anil
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AU - Khader, Yousef Saleh
AU - Khafaie, Morteza Abdullatif
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AU - Koyanagi, Ai
AU - Krishnamurthi, Rita V.
AU - Kuate Defo, Barthelemy
AU - Kucuk Bicer, Burcu
AU - Kumar, Manasi
AU - Lacey, Ben
AU - Lafranconi, Alessandra
AU - Lansingh, Van C.
AU - Latifi, Arman
AU - Leshargie, Cheru Tesema
AU - Li, Shanshan
AU - Liao, Yu
AU - Linn, Shai
AU - Lo, Warren David
AU - Lopez, Jaifred Christian F.
AU - Lorkowski, Stefan
AU - Lotufo, Paulo A.
AU - Lucas, Robyn M.
AU - Lunevicius, Raimundas
AU - Mackay, Mark T.
AU - Mahotra, Narayan Bahadur
AU - Majdan, Marek
AU - Majdzadeh, Reza
AU - Majeed, Azeem
AU - Malekzadeh, Reza
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AU - Manafi, Navid
AU - Mansournia, Mohammad Ali
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AU - Massenburg, Benjamin Ballard
AU - Mate, Kedar K.V.
AU - McAlinden, Colm
AU - McGrath, John J.
AU - Mehta, Varshil
AU - Meier, Toni
AU - Meles, Hagazi Gebre
AU - Melese, Addisu
AU - Memiah, Peter T.N.
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AU - Mendoza, Walter
AU - Mengistu, Desalegn Tadese
AU - Mengistu, Getnet
AU - Meretoja, Atte
AU - Meretoja, Tuomo J.
AU - Mestrovic, Tomislav
AU - Miazgowski, Bartosz
AU - Miazgowski, Tomasz
AU - Miller, Ted R.
AU - Mini, G. K.
AU - Mirrakhimov, Erkin M.
AU - Moazen, Babak
AU - Mohajer, Bahram
AU - Mohammad Gholi Mezerji, Naser
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AU - Mohammadi-Khanaposhtani, Maryam
AU - Mohammadibakhsh, Roghayeh
AU - Mohammadnia-Afrouzi, Mousa
AU - Mohammed, Shafiu
AU - Mohebi, Farnam
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AU - Monasta, Lorenzo
AU - Mondello, Stefania
AU - Moodley, Yoshan
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AU - Moradi, Ghobad
AU - Moradi-Lakeh, Maziar
AU - Moradinazar, Mehdi
AU - Moraga, Paula
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N1 - Generated from Scopus record by KAUST IRTS on 2021-03-16
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders. Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach. Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer's and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable). Interpretation: Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies. Funding: Bill & Melinda Gates Foundation.
AB - Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders. Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach. Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer's and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable). Interpretation: Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies. Funding: Bill & Melinda Gates Foundation.
UR - https://linkinghub.elsevier.com/retrieve/pii/S147444221830499X
UR - http://www.scopus.com/inward/record.url?scp=85064086327&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(18)30499-X
DO - 10.1016/S1474-4422(18)30499-X
M3 - Article
SN - 1474-4465
VL - 18
SP - 459
EP - 480
JO - The Lancet Neurology
JF - The Lancet Neurology
IS - 5
ER -