Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines

Yan Zhang, Choonwee Kee, Richmond Lee, Xiao Fu, J. Y T Soh, E. M F Loh, Kuo-Wei Huang, Choonhong Tan

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


An amino-indanol derived chiral guanidine was developed as an efficient Brønsted base catalyst for the desymmetrization of meso-aziridines with both thiols and carbamodithioic acids as nucleophiles, which provided 1,2-difunctionalized ring-opened products in high yields and enantioselectivities. © The Royal Society of Chemistry.
Original languageEnglish (US)
Pages (from-to)3897
JournalChemical Communications
Issue number13
StatePublished - 2011

ASJC Scopus subject areas

  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Ceramics and Composites
  • General Chemistry
  • Catalysis
  • Electronic, Optical and Magnetic Materials


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