Hepatitis C Virus: Virology and Genotypes

Ahmed Abdelaziz

doi:10.1016/B978-0-12-803233-6.00001-1

Hepatitis C Virus: Virology and Genotypes

Ahmed Abdelaziz

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Hepatitis C virus (HCV) is a major causative agent of chronic liver disease worldwide. HCV is characterized by genetic heterogeneity, with at least six genotypes identified. The geographic distribution of genotypes has shown variations in different parts of the world over the past decade because of variations in population structure, immigration, and routes of transmission. Genotype differences are of epidemiologic interest and help the study of viral transmission dynamics to trace the source of HCV infection in a given population. HCV genotypes are also of considerable clinical importance because they affect response to antiviral therapy and represent a challenging obstacle for vaccine development.

Original language	English (US)
Title of host publication	Hepatitis C in Developing Countries
Publisher	Elsevier BV
Pages	3-11
Number of pages	9
ISBN (Print)	9780128032336
DOIs	https://doi.org/10.1016/B978-0-12-803233-6.00001-1
State	Published - Dec 1 2017

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title = "Hepatitis C Virus: Virology and Genotypes",

abstract = "Hepatitis C virus (HCV) is a major causative agent of chronic liver disease worldwide. HCV is characterized by genetic heterogeneity, with at least six genotypes identified. The geographic distribution of genotypes has shown variations in different parts of the world over the past decade because of variations in population structure, immigration, and routes of transmission. Genotype differences are of epidemiologic interest and help the study of viral transmission dynamics to trace the source of HCV infection in a given population. HCV genotypes are also of considerable clinical importance because they affect response to antiviral therapy and represent a challenging obstacle for vaccine development.",

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N2 - Hepatitis C virus (HCV) is a major causative agent of chronic liver disease worldwide. HCV is characterized by genetic heterogeneity, with at least six genotypes identified. The geographic distribution of genotypes has shown variations in different parts of the world over the past decade because of variations in population structure, immigration, and routes of transmission. Genotype differences are of epidemiologic interest and help the study of viral transmission dynamics to trace the source of HCV infection in a given population. HCV genotypes are also of considerable clinical importance because they affect response to antiviral therapy and represent a challenging obstacle for vaccine development.

AB - Hepatitis C virus (HCV) is a major causative agent of chronic liver disease worldwide. HCV is characterized by genetic heterogeneity, with at least six genotypes identified. The geographic distribution of genotypes has shown variations in different parts of the world over the past decade because of variations in population structure, immigration, and routes of transmission. Genotype differences are of epidemiologic interest and help the study of viral transmission dynamics to trace the source of HCV infection in a given population. HCV genotypes are also of considerable clinical importance because they affect response to antiviral therapy and represent a challenging obstacle for vaccine development.

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BT - Hepatitis C in Developing Countries

PB - Elsevier BV

ER -

Hepatitis C Virus: Virology and Genotypes

Abstract

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