@article{957e679cd34d40e2873b0367c372ca4b,
title = "High-Throughput Screening of the Asymmetric Decarboxylative Alkylation Reaction of Enolate-Stabilized Enol Carbonates",
abstract = "The use of high-throughput screening allowed for the optimization of reaction conditions for the palladium-catalyzed asymmetric decarboxylative alkylation reaction of enolate-stabilized enol carbonates. Changing to a non-polar reaction solvent and to an electron-deficient PHOX derivative as ligand from our standard reaction conditions improved the enantioselectivity for the alkylation of a ketal-protected,1,3-diketone-derived enol carbonate from 28% ee to 84% ee. Similar improvements in enantioselectivity were seen for a β-keto-ester derived- and an α-phenyl cyclohexanone-derived enol carbonate.",
author = "Brian Stoltz and Nolan McDougal and Scott Virgil",
note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): KUS-11- 006-02 Acknowledgements: This publication is based on work supported by Award No. KUS-11- 006-02, made by King Abdullah University of Science and Technology (KAUST). Additionally, the authors wish to thank NIH-NIGMS (R01 GM 080269-01), Abbott Laboratories, Amgen, the Gordon and Betty Moore Foundation, and Caltech for financial support. This publication acknowledges KAUST support, but has no KAUST affiliated authors.",
year = "2010",
month = jun,
day = "14",
doi = "10.1055/s-0030-1258094",
language = "English (US)",
volume = "2010",
pages = "1712--1716",
journal = "Synlett",
issn = "0936-5214",
publisher = "Georg Thieme Verlag",
number = "11",
}