Highly selective chiral recognition on polymer supports: Preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands

Kevin Lewandowski; Peter Murer; Frantisek Svec; Jean M.J. Fréchet

doi:10.1039/a806395h

Highly selective chiral recognition on polymer supports: Preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands

Kevin Lewandowski, Peter Murer, Frantisek Svec, Jean M.J. Fréchet^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

A library of more than 140 racemic 4-aryl-1,4-dihydropyrimidines has been synthesized using the single step Biginelli multicomponent condensation; the individual compounds were screened for enantiomer resolution, and the best candidate attached to a solid macroporous polymer support to afford a highly selective separation medium for chiral HPLC.

Original language	English (US)
Pages (from-to)	2237-2238
Number of pages	2
Journal	CHEMICAL COMMUNICATIONS
Issue number	20
DOIs	https://doi.org/10.1039/a806395h
State	Published - Oct 21 1998
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/a806395h

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abstract = "A library of more than 140 racemic 4-aryl-1,4-dihydropyrimidines has been synthesized using the single step Biginelli multicomponent condensation; the individual compounds were screened for enantiomer resolution, and the best candidate attached to a solid macroporous polymer support to afford a highly selective separation medium for chiral HPLC.",

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AU - Fréchet, Jean M.J.

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AB - A library of more than 140 racemic 4-aryl-1,4-dihydropyrimidines has been synthesized using the single step Biginelli multicomponent condensation; the individual compounds were screened for enantiomer resolution, and the best candidate attached to a solid macroporous polymer support to afford a highly selective separation medium for chiral HPLC.

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Highly selective chiral recognition on polymer supports: Preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands

Abstract

ASJC Scopus subject areas

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