Highly selective chiral recognition on polymer supports: Preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands

Kevin Lewandowski; Peter Murer; Frantisek Svec; Jean M J Fréchet

Highly selective chiral recognition on polymer supports: Preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands

Kevin Lewandowski, Peter Murer, Frantisek Svec, Jean M J Fréchet^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

A library of more than 140 racemic 4-aryl-1,4-dihydropyrimidines has been synthesized using the single step Biginelli multicomponent condensation; the individual compounds were screened for enantiomer resolution, and the best candidate attached to a solid macroporous polymer support to afford a highly selective separation medium for chiral HPLC.

Original language	English (US)
Pages (from-to)	2237-2238
Number of pages	2
Journal	Chemical Communications
Issue number	20
State	Published - Oct 21 1998
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

Cite this

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title = "Highly selective chiral recognition on polymer supports: Preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands",

abstract = "A library of more than 140 racemic 4-aryl-1,4-dihydropyrimidines has been synthesized using the single step Biginelli multicomponent condensation; the individual compounds were screened for enantiomer resolution, and the best candidate attached to a solid macroporous polymer support to afford a highly selective separation medium for chiral HPLC.",

author = "Kevin Lewandowski and Peter Murer and Frantisek Svec and Fr{\'e}chet, {Jean M J}",

year = "1998",

month = oct,

day = "21",

language = "English (US)",

pages = "2237--2238",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "ROYAL SOC CHEMISTRY",

number = "20",

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T1 - Highly selective chiral recognition on polymer supports

T2 - Preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands

AU - Lewandowski, Kevin

AU - Murer, Peter

AU - Svec, Frantisek

AU - Fréchet, Jean M J

PY - 1998/10/21

Y1 - 1998/10/21

N2 - A library of more than 140 racemic 4-aryl-1,4-dihydropyrimidines has been synthesized using the single step Biginelli multicomponent condensation; the individual compounds were screened for enantiomer resolution, and the best candidate attached to a solid macroporous polymer support to afford a highly selective separation medium for chiral HPLC.

AB - A library of more than 140 racemic 4-aryl-1,4-dihydropyrimidines has been synthesized using the single step Biginelli multicomponent condensation; the individual compounds were screened for enantiomer resolution, and the best candidate attached to a solid macroporous polymer support to afford a highly selective separation medium for chiral HPLC.

UR - http://www.scopus.com/inward/record.url?scp=0001858454&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0001858454

SN - 1359-7345

SP - 2237

EP - 2238

JO - Chemical Communications

JF - Chemical Communications

IS - 20

ER -

Highly selective chiral recognition on polymer supports: Preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands

Abstract

ASJC Scopus subject areas

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