Highly sensitive determination of non-steroidal anti-inflammatory drug nimesulide using electrochemically reduced graphene oxide nanoribbons

Mani Govindasamy; Veerappan Mani; Shen Ming Chen; Thandavarayan Maiyalagan; S. Selvaraj; Tse Wei Chen; Shih Yi Lee; Wen Han Chang

doi:10.1039/c7ra02844j

Highly sensitive determination of non-steroidal anti-inflammatory drug nimesulide using electrochemically reduced graphene oxide nanoribbons

Mani Govindasamy, Veerappan Mani, Shen Ming Chen, Thandavarayan Maiyalagan, S. Selvaraj, Tse Wei Chen, Shih Yi Lee, Wen Han Chang

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

The excess use of nimesulide (NIM) causes acute side effects to gastrointestinal, central nervous and genitourinary systems and hence its rapid, sensitive determination is highly important. We describe a robust electrochemical sensor based on electrochemically reduced graphene oxide nanoribbons (ER-GONRs) modified on a screen-printed carbon electrode (SPCE) for detecting NIM in pharmaceutical formulations and biological medium. Compared with parental multiwalled carbon nanotubes (MWCNTs), ER-GONRs possess rich edge defects, abundant functional groups, high area-normalized edge-plane structures and chemically active sites and hence they can be a superior electrocatalyst and signal amplifier for electroanalytical applications. ER-GONRs/SPCE exhibited excellent sensing performance towards NIM. The linear range was 1.0 × 10-8 to 1.50 × 10-3 M and the detection limit was 3.50 (±1.57) nM. In addition, the ER-GONRs/SPCE showed excellent real-time sensing applications in NIM tablet and human urine samples, which could find potential applicability in drug and clinical analysis. The combined advantages of SPCE technology and ER-GONRs make this method a robust, low-cost, reproducible, sensitive and easy-to-use sensor.

Original language	English (US)
Pages (from-to)	33043-33051
Number of pages	9
Journal	RSC ADVANCES
Volume	7
Issue number	52
DOIs	https://doi.org/10.1039/c7ra02844j
State	Published - Jan 1 2017
Externally published	Yes

ASJC Scopus subject areas

General Chemical Engineering
General Chemistry

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title = "Highly sensitive determination of non-steroidal anti-inflammatory drug nimesulide using electrochemically reduced graphene oxide nanoribbons",

abstract = "The excess use of nimesulide (NIM) causes acute side effects to gastrointestinal, central nervous and genitourinary systems and hence its rapid, sensitive determination is highly important. We describe a robust electrochemical sensor based on electrochemically reduced graphene oxide nanoribbons (ER-GONRs) modified on a screen-printed carbon electrode (SPCE) for detecting NIM in pharmaceutical formulations and biological medium. Compared with parental multiwalled carbon nanotubes (MWCNTs), ER-GONRs possess rich edge defects, abundant functional groups, high area-normalized edge-plane structures and chemically active sites and hence they can be a superior electrocatalyst and signal amplifier for electroanalytical applications. ER-GONRs/SPCE exhibited excellent sensing performance towards NIM. The linear range was 1.0 × 10-8 to 1.50 × 10-3 M and the detection limit was 3.50 (±1.57) nM. In addition, the ER-GONRs/SPCE showed excellent real-time sensing applications in NIM tablet and human urine samples, which could find potential applicability in drug and clinical analysis. The combined advantages of SPCE technology and ER-GONRs make this method a robust, low-cost, reproducible, sensitive and easy-to-use sensor.",

author = "Mani Govindasamy and Veerappan Mani and Chen, {Shen Ming} and Thandavarayan Maiyalagan and S. Selvaraj and Chen, {Tse Wei} and Lee, {Shih Yi} and Chang, {Wen Han}",

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T1 - Highly sensitive determination of non-steroidal anti-inflammatory drug nimesulide using electrochemically reduced graphene oxide nanoribbons

AU - Govindasamy, Mani

AU - Mani, Veerappan

AU - Chen, Shen Ming

AU - Maiyalagan, Thandavarayan

AU - Selvaraj, S.

AU - Chen, Tse Wei

AU - Lee, Shih Yi

AU - Chang, Wen Han

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AB - The excess use of nimesulide (NIM) causes acute side effects to gastrointestinal, central nervous and genitourinary systems and hence its rapid, sensitive determination is highly important. We describe a robust electrochemical sensor based on electrochemically reduced graphene oxide nanoribbons (ER-GONRs) modified on a screen-printed carbon electrode (SPCE) for detecting NIM in pharmaceutical formulations and biological medium. Compared with parental multiwalled carbon nanotubes (MWCNTs), ER-GONRs possess rich edge defects, abundant functional groups, high area-normalized edge-plane structures and chemically active sites and hence they can be a superior electrocatalyst and signal amplifier for electroanalytical applications. ER-GONRs/SPCE exhibited excellent sensing performance towards NIM. The linear range was 1.0 × 10-8 to 1.50 × 10-3 M and the detection limit was 3.50 (±1.57) nM. In addition, the ER-GONRs/SPCE showed excellent real-time sensing applications in NIM tablet and human urine samples, which could find potential applicability in drug and clinical analysis. The combined advantages of SPCE technology and ER-GONRs make this method a robust, low-cost, reproducible, sensitive and easy-to-use sensor.

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Highly sensitive determination of non-steroidal anti-inflammatory drug nimesulide using electrochemically reduced graphene oxide nanoribbons

Abstract

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