Hologenome analysis of two marine sponges with different microbiomes

Tae Woo Ryu, Loqmane Seridi, Lucas Moitinho-Silva, Matthew Oates, Yi Jin Liew, Charalampos Harris Mavromatis, Xiaolei Wang, Annika Haywood, Feras Fawzi Lafi, Marija Kupresanin, Rachid Sougrat, Majed A. Alzahrani, Emily Giles, Yanal Ghosheh, Celia Marei Schunter, Sebastian Baumgarten, Michael L. Berumen, Xin Gao, Manuel Aranda, Sylvain ForetJulian Gough, Christian R. Voolstra, Ute Hentschel, Timothy Ravasi

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Background Sponges (Porifera) harbor distinct microbial consortia within their mesohyl interior. We herein analysed the hologenomes of Stylissa carteri and Xestospongia testudinaria, which notably differ in their microbiome content. Results Our analysis revealed that S. carteri has an expanded repertoire of immunological domains, specifically Scavenger Receptor Cysteine-Rich (SRCR)-like domains, compared to X. testudinaria. On the microbial side, metatranscriptome analyses revealed an overrepresentation of potential symbiosis-related domains in X. testudinaria. Conclusions Our findings provide genomic insights into the molecular mechanisms underlying host-symbiont coevolution and may serve as a roadmap for future hologenome analyses.
Original languageEnglish (US)
JournalBMC Genomics
Issue number1
StatePublished - Feb 29 2016


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