TY - JOUR
T1 - Host-directed editing of the SARS-CoV-2 genome.
AU - Mourier, Tobias
AU - Sadykov, Mukhtar
AU - Carr, Michael J
AU - Gonzalez, Gabriel
AU - Hall, William W
AU - Pain, Arnab
N1 - KAUST Repository Item: Exported on 2020-12-02
Acknowledged KAUST grant number(s): BAS/1/1020-01-01
Acknowledgements: We thank all laboratories which have contributed sequences to the GISAID database.
This work was supported by funding from King Abdullah University of Science and Technology (KAUST), Office of Sponsored Research (OSR). Work in AP’s laboratory is supported by the KAUST faculty baseline fund (BAS/1/1020-01-01) and the R3T initiative of KAUST.
PY - 2020/11/25
Y1 - 2020/11/25
N2 - The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
AB - The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
UR - http://hdl.handle.net/10754/666152
UR - https://linkinghub.elsevier.com/retrieve/pii/S0006291X20320210
U2 - 10.1016/j.bbrc.2020.10.092
DO - 10.1016/j.bbrc.2020.10.092
M3 - Article
C2 - 33234239
SN - 0006-291X
JO - Biochemical and biophysical research communications
JF - Biochemical and biophysical research communications
ER -