How focal adhesion kinase achieves regulation by linking ligand binding, localization and action

Stefan T. Arold

doi:10.1016/j.sbi.2011.09.008

How focal adhesion kinase achieves regulation by linking ligand binding, localization and action

Stefan T. Arold^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

Focal adhesion kinase (FAK) has an astonishing number of ligands and functions, which enable it to contribute to embryonic development and human health. FAK can promote different effects in similar cellular environments or similar effects in different cellular environments. Recent advances in structural and cellular analysis of FAK are starting to reveal the interrelationships between the conformations, localizations, interactions, and functions of FAK. This review focuses on our emerging understanding of how the structural framework of FAK mechanistically allows it to integrate manifold stimuli into environment-specific functions.

Original language	English (US)
Pages (from-to)	808-813
Number of pages	6
Journal	Current Opinion in Structural Biology
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/j.sbi.2011.09.008
State	Published - Dec 2011
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Structural Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.sbi.2011.09.008

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title = "How focal adhesion kinase achieves regulation by linking ligand binding, localization and action",

abstract = "Focal adhesion kinase (FAK) has an astonishing number of ligands and functions, which enable it to contribute to embryonic development and human health. FAK can promote different effects in similar cellular environments or similar effects in different cellular environments. Recent advances in structural and cellular analysis of FAK are starting to reveal the interrelationships between the conformations, localizations, interactions, and functions of FAK. This review focuses on our emerging understanding of how the structural framework of FAK mechanistically allows it to integrate manifold stimuli into environment-specific functions.",

author = "Arold, {Stefan T.}",

note = "Funding Information: I apologize to all colleagues whose work could not be explicitly mentioned due to restrictions in space and number of references. I thank J.-A. Girault, D. Arsenieva, Z. Lu and J.E. Ladbury for critical reading of this manuscript and K. Muller for editorial assistance. This research is supported in part by the National Institutes of Health through MD Anderson's Cancer Center Support Grant ( CA016672 ). This research was supported by the University Cancer Foundation via the Institutional Research Grant program at the University of Texas MD Anderson Cancer Center.",

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doi = "10.1016/j.sbi.2011.09.008",

language = "English (US)",

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PY - 2011/12

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N2 - Focal adhesion kinase (FAK) has an astonishing number of ligands and functions, which enable it to contribute to embryonic development and human health. FAK can promote different effects in similar cellular environments or similar effects in different cellular environments. Recent advances in structural and cellular analysis of FAK are starting to reveal the interrelationships between the conformations, localizations, interactions, and functions of FAK. This review focuses on our emerging understanding of how the structural framework of FAK mechanistically allows it to integrate manifold stimuli into environment-specific functions.

AB - Focal adhesion kinase (FAK) has an astonishing number of ligands and functions, which enable it to contribute to embryonic development and human health. FAK can promote different effects in similar cellular environments or similar effects in different cellular environments. Recent advances in structural and cellular analysis of FAK are starting to reveal the interrelationships between the conformations, localizations, interactions, and functions of FAK. This review focuses on our emerging understanding of how the structural framework of FAK mechanistically allows it to integrate manifold stimuli into environment-specific functions.

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M3 - Review article

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SP - 808

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JO - Current Opinion in Structural Biology

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How focal adhesion kinase achieves regulation by linking ligand binding, localization and action

Abstract

ASJC Scopus subject areas

UN SDGs

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