TY - JOUR
T1 - How pathogens use linear motifs to perturb host cell networks
AU - Via, Allegra
AU - Uyar, Bora
AU - Brun, Christine
AU - Zanzoni, Andreas
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): KUK-I1-012-43
Acknowledgements: The authors are grateful to David G. Biron (CNRS, France), Toby J. Gibson (EMBL, Germany), and Vincenzo Petrarca (Sapienza University, Italy) for critically reading the manuscript and providing fruitful suggestions. A.V. acknowledges the King Abdullah University of Science and Technology (KAUST) Award No. KUK-I1-012-43 for funding support. C.B. and A.Z. received financial support from the French 'Plan Cancer 2009-2013' (Systems Biology call, A12171AS).
This publication acknowledges KAUST support, but has no KAUST affiliated authors.
PY - 2015/1
Y1 - 2015/1
N2 - Molecular mimicry is one of the powerful stratagems that pathogens employ to colonise their hosts and take advantage of host cell functions to guarantee their replication and dissemination. In particular, several viruses have evolved the ability to interact with host cell components through protein short linear motifs (SLiMs) that mimic host SLiMs, thus facilitating their internalisation and the manipulation of a wide range of cellular networks. Here we present convincing evidence from the literature that motif mimicry also represents an effective, widespread hijacking strategy in prokaryotic and eukaryotic parasites. Further insights into host motif mimicry would be of great help in the elucidation of the molecular mechanisms behind host cell invasion and the development of anti-infective therapeutic strategies.
AB - Molecular mimicry is one of the powerful stratagems that pathogens employ to colonise their hosts and take advantage of host cell functions to guarantee their replication and dissemination. In particular, several viruses have evolved the ability to interact with host cell components through protein short linear motifs (SLiMs) that mimic host SLiMs, thus facilitating their internalisation and the manipulation of a wide range of cellular networks. Here we present convincing evidence from the literature that motif mimicry also represents an effective, widespread hijacking strategy in prokaryotic and eukaryotic parasites. Further insights into host motif mimicry would be of great help in the elucidation of the molecular mechanisms behind host cell invasion and the development of anti-infective therapeutic strategies.
UR - http://hdl.handle.net/10754/598519
UR - https://linkinghub.elsevier.com/retrieve/pii/S0968000414002059
UR - http://www.scopus.com/inward/record.url?scp=84963980075&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2014.11.001
DO - 10.1016/j.tibs.2014.11.001
M3 - Article
C2 - 25475989
SN - 0968-0004
VL - 40
SP - 36
EP - 48
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 1
ER -