Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice

Timothy K Cooper; Kathleen A Silva; Victoria E Kennedy; Sarah Alghamdi; Robert Hoehndorf; Beth A Sundberg; Paul N Schofield; John P Sundberg

doi:10.1177/0300985819844822

Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice

Timothy K Cooper, Kathleen A Silva, Victoria E Kennedy, Sarah Alghamdi, Robert Hoehndorf, Beth A Sundberg, Paul N Schofield, John P Sundberg

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Abstract

During a screen for vascular phenotypes in aged laboratory mice, a unique discrete phenotype of hyaline arteriolosclerosis of the intertubular arteries and arterioles of the testes was identified in several inbred strains. Lesions were limited to the testes and did not occur as part of any renal, systemic, or pulmonary arteriopathy or vasculitis phenotype. There was no evidence of systemic or pulmonary hypertension, and lesions did not occur in ovaries of females. Frequency was highest in males of the SM/J (27/30, 90%) and WSB/EiJ (19/26, 73%) strains, aged 383 to 847 days. Lesions were sporadically present in males from several other inbred strains at a much lower (

Original language	English (US)
Pages (from-to)	799-806
Number of pages	8
Journal	Veterinary Pathology
Volume	56
Issue number	5
DOIs	https://doi.org/10.1177/0300985819844822
State	Published - May 6 2019

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10.1177/0300985819844822

https://repository.kaust.edu.sa/bitstream/10754/652815/1/Arteriolosclerosis%20in%20aging%20mice%20Vet%20Path.pdf

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title = "Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice",

abstract = "During a screen for vascular phenotypes in aged laboratory mice, a unique discrete phenotype of hyaline arteriolosclerosis of the intertubular arteries and arterioles of the testes was identified in several inbred strains. Lesions were limited to the testes and did not occur as part of any renal, systemic, or pulmonary arteriopathy or vasculitis phenotype. There was no evidence of systemic or pulmonary hypertension, and lesions did not occur in ovaries of females. Frequency was highest in males of the SM/J (27/30, 90%) and WSB/EiJ (19/26, 73%) strains, aged 383 to 847 days. Lesions were sporadically present in males from several other inbred strains at a much lower (",

author = "Cooper, {Timothy K} and Silva, {Kathleen A} and Kennedy, {Victoria E} and Sarah Alghamdi and Robert Hoehndorf and Sundberg, {Beth A} and Schofield, {Paul N} and Sundberg, {John P}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: National Cancer Institute[CA034196]",

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T1 - Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice

AU - Cooper, Timothy K

AU - Silva, Kathleen A

AU - Kennedy, Victoria E

AU - Alghamdi, Sarah

AU - Hoehndorf, Robert

AU - Sundberg, Beth A

AU - Schofield, Paul N

AU - Sundberg, John P

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: National Cancer Institute[CA034196]

PY - 2019/5/6

Y1 - 2019/5/6

N2 - During a screen for vascular phenotypes in aged laboratory mice, a unique discrete phenotype of hyaline arteriolosclerosis of the intertubular arteries and arterioles of the testes was identified in several inbred strains. Lesions were limited to the testes and did not occur as part of any renal, systemic, or pulmonary arteriopathy or vasculitis phenotype. There was no evidence of systemic or pulmonary hypertension, and lesions did not occur in ovaries of females. Frequency was highest in males of the SM/J (27/30, 90%) and WSB/EiJ (19/26, 73%) strains, aged 383 to 847 days. Lesions were sporadically present in males from several other inbred strains at a much lower (

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Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice

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