Hydrophilization of Porous Polystyrene-Based Continuous Rod Column

Q. Ching Wang; Frantisek Svec; Jean M.J. Fréchet

doi:10.1021/ac00099a028

Hydrophilization of Porous Polystyrene-Based Continuous Rod Column

Q. Ching Wang, Frantisek Svec, Jean M.J. Fréchet^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Reactive porous rods of poly[(chloromethyl)styrene-codivinylbenzene] have been prepared for the first time by copolymerization of the monomers in the presence of a porogenic diluent A two-step modification process involving reaction with ethyienediamine followed%reaction with γ-gluconolactone leads to a porous medium that has highly hydrophilic surface functionalities. Preliminary chromatographic evaluation with both small molecules such as alkylbenzenes in reversed-phase mode and large proteins in hydrophobic adsorption and ion-exchange modes demonstrates that the surface of the modified rods possesses a hydrophilicity that is comparable to that of the best hydrophilic HPLC packings.

Original language	English (US)
Pages (from-to)	670-674
Number of pages	5
Journal	ANALYTICAL CHEMISTRY
Volume	67
Issue number	3
DOIs	https://doi.org/10.1021/ac00099a028
State	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry

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title = "Hydrophilization of Porous Polystyrene-Based Continuous Rod Column",

abstract = "Reactive porous rods of poly[(chloromethyl)styrene-codivinylbenzene] have been prepared for the first time by copolymerization of the monomers in the presence of a porogenic diluent A two-step modification process involving reaction with ethyienediamine followed%reaction with γ-gluconolactone leads to a porous medium that has highly hydrophilic surface functionalities. Preliminary chromatographic evaluation with both small molecules such as alkylbenzenes in reversed-phase mode and large proteins in hydrophobic adsorption and ion-exchange modes demonstrates that the surface of the modified rods possesses a hydrophilicity that is comparable to that of the best hydrophilic HPLC packings.",

author = "Wang, {Q. Ching} and Frantisek Svec and Fr{\'e}chet, {Jean M.J.}",

year = "1995",

doi = "10.1021/ac00099a028",

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AU - Wang, Q. Ching

AU - Svec, Frantisek

AU - Fréchet, Jean M.J.

PY - 1995

Y1 - 1995

N2 - Reactive porous rods of poly[(chloromethyl)styrene-codivinylbenzene] have been prepared for the first time by copolymerization of the monomers in the presence of a porogenic diluent A two-step modification process involving reaction with ethyienediamine followed%reaction with γ-gluconolactone leads to a porous medium that has highly hydrophilic surface functionalities. Preliminary chromatographic evaluation with both small molecules such as alkylbenzenes in reversed-phase mode and large proteins in hydrophobic adsorption and ion-exchange modes demonstrates that the surface of the modified rods possesses a hydrophilicity that is comparable to that of the best hydrophilic HPLC packings.

AB - Reactive porous rods of poly[(chloromethyl)styrene-codivinylbenzene] have been prepared for the first time by copolymerization of the monomers in the presence of a porogenic diluent A two-step modification process involving reaction with ethyienediamine followed%reaction with γ-gluconolactone leads to a porous medium that has highly hydrophilic surface functionalities. Preliminary chromatographic evaluation with both small molecules such as alkylbenzenes in reversed-phase mode and large proteins in hydrophobic adsorption and ion-exchange modes demonstrates that the surface of the modified rods possesses a hydrophilicity that is comparable to that of the best hydrophilic HPLC packings.

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Hydrophilization of Porous Polystyrene-Based Continuous Rod Column

Abstract

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