TY - JOUR
T1 - Identification and predictive value of interleukin-6+ interleukin-10+ and interleukin-6-interleukin-10+ cytokine patterns in st-elevation acute myocardial infarction
AU - Ammirati, Enrico
AU - Cannistraci, Carlo
AU - Cristell, Nicole A.
AU - Vecchio, Viviana
AU - Palini, Alessio G.
AU - Tornvall, Per
AU - Paganoni, Anna Maria
AU - Miendlarzewska, Ewa A.
AU - Sangalli, Laura Maria
AU - Monello, Alberto
AU - Pernow, John
AU - Björnstedt Bennermo, Marie
AU - Marenzi, Giancarlo Carlo
AU - Hu, Dayi
AU - Uren, Neal G.
AU - Cianflone, Domenico
AU - Ravasi, Timothy
AU - Manfredi, Angelo A.
AU - Maseri, Attilio
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: E. Ammirati received financial support from Giovane Ricercatore 2009 Grant from the Italian Health Ministry (project code GR-2009-1608780) and from the Heart Care Foundation, Florence, Italy. C. V. Cannistraci was supported by the Italian Interpolytechnic School of Doctorate (SIPD). T. Ravasi and C. V. Cannistraci received financial support from King Abdullah University of Science and Technology, Saudi Arabia.
PY - 2012/8/29
Y1 - 2012/8/29
N2 - RATIONALE: At the onset of ST-elevation acute myocardial infarction (STEMI), patients can present with very high circulating interleukin-6 (IL-6) levels or very low-IL-6 levels. OBJECTIVE: We compared these 2 groups of patients to understand whether it is possible to define specific STEMI phenotypes associated with outcome based on the cytokine response. METHODS AND RESULTS: We compared 109 patients with STEMI in the top IL-6 level (median, 15.6 pg/mL; IL-6 STEMI) with 96 in the bottom IL-6 level (median, 1.7 pg/mL; IL-6 STEMI) and 103 matched controls extracted from the multiethnic First Acute Myocardial Infarction study. We found minimal clinical differences between IL-6 STEMI and IL-6 STEMI. We assessed the inflammatory profiles of the 2 STEMI groups and the controls by measuring 18 cytokines in blood samples. We exploited clustering analysis algorithms to infer the functional modules of interacting cytokines. IL-6 STEMI patients were characterized by the activation of 2 modules of interacting signals comprising IL-10, IL-8, macrophage inflammatory protein-1α, and C-reactive protein, and monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, and monokine induced by interferon-γ. IL-10 was increased both in IL-6 STEMI and IL-6 STEMI patients compared with controls. IL-6IL-10 STEMI patients had an increased risk of systolic dysfunction at discharge and an increased risk of death at 6 months in comparison with IL-6IL-10 STEMI patients. We combined IL-10 and monokine induced by interferon-γ (derived from the 2 identified cytokine modules) with IL-6 in a formula yielding a risk index that outperformed any single cytokine in the prediction of systolic dysfunction and death. CONCLUSIONS: We have identified a characteristic circulating inflammatory cytokine pattern in STEMI patients, which is not related to the extent of myocardial damage. The simultaneous elevation of IL-6 and IL-10 levels distinguishes STEMI patients with worse clinical outcomes from other STEMI patients. These observations could have potential implications for risk-oriented patient stratification and immune-modulating therapies. © 2012 American Heart Association, Inc.
AB - RATIONALE: At the onset of ST-elevation acute myocardial infarction (STEMI), patients can present with very high circulating interleukin-6 (IL-6) levels or very low-IL-6 levels. OBJECTIVE: We compared these 2 groups of patients to understand whether it is possible to define specific STEMI phenotypes associated with outcome based on the cytokine response. METHODS AND RESULTS: We compared 109 patients with STEMI in the top IL-6 level (median, 15.6 pg/mL; IL-6 STEMI) with 96 in the bottom IL-6 level (median, 1.7 pg/mL; IL-6 STEMI) and 103 matched controls extracted from the multiethnic First Acute Myocardial Infarction study. We found minimal clinical differences between IL-6 STEMI and IL-6 STEMI. We assessed the inflammatory profiles of the 2 STEMI groups and the controls by measuring 18 cytokines in blood samples. We exploited clustering analysis algorithms to infer the functional modules of interacting cytokines. IL-6 STEMI patients were characterized by the activation of 2 modules of interacting signals comprising IL-10, IL-8, macrophage inflammatory protein-1α, and C-reactive protein, and monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, and monokine induced by interferon-γ. IL-10 was increased both in IL-6 STEMI and IL-6 STEMI patients compared with controls. IL-6IL-10 STEMI patients had an increased risk of systolic dysfunction at discharge and an increased risk of death at 6 months in comparison with IL-6IL-10 STEMI patients. We combined IL-10 and monokine induced by interferon-γ (derived from the 2 identified cytokine modules) with IL-6 in a formula yielding a risk index that outperformed any single cytokine in the prediction of systolic dysfunction and death. CONCLUSIONS: We have identified a characteristic circulating inflammatory cytokine pattern in STEMI patients, which is not related to the extent of myocardial damage. The simultaneous elevation of IL-6 and IL-10 levels distinguishes STEMI patients with worse clinical outcomes from other STEMI patients. These observations could have potential implications for risk-oriented patient stratification and immune-modulating therapies. © 2012 American Heart Association, Inc.
UR - http://hdl.handle.net/10754/562282
UR - https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.111.262477
UR - http://www.scopus.com/inward/record.url?scp=84868711085&partnerID=8YFLogxK
U2 - 10.1161/CIRCRESAHA.111.262477
DO - 10.1161/CIRCRESAHA.111.262477
M3 - Article
C2 - 22931953
SN - 0009-7330
VL - 111
SP - 1336
EP - 1348
JO - Circulation Research
JF - Circulation Research
IS - 10
ER -