Impact of MCT1 haploinsufficiency on the mouse retina

Neal S. Peachey*, Minzhong Yu, John Y.S. Han, Sylvain Lengacher, Pierre J. Magistretti, Luc Pellerin, Nancy J. Philp

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations


The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1 +/− heterozygotes, which express half of the normal complement of MCT1. The MCT1 +/− retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Number of pages6
StatePublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Electroretinogram
  • Lactate
  • MCT1
  • Retina
  • Transgenic mice

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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