TY - JOUR
T1 - Improving the Compatibility of Diketopyrrolopyrrole (DPP) Semiconducting Polymers for Biological Interfacing by Lysine Attachment
AU - du, weiyuan
AU - ohayon, David
AU - Combe, Craig
AU - Mottier, Lorene
AU - Maria, Iuliana P.
AU - Ashraf, Raja
AU - Fiumelli, Hubert
AU - Inal, Sahika
AU - McCulloch, Iain
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): OSR-2016-CRG5-3003
Acknowledgements: We acknowledge funding from KAUST, as well as EPSRC Project EP/G037515/1, EP/M005143/1, ECFP7 Project SC2 (610115), for the financial support. D.O, S.I. and I.M. gratefully acknowledge financial support from the KAUST Office of Sponsored Research (OSR) under Award No. OSR-2016-CRG5-3003.
PY - 2018/8/17
Y1 - 2018/8/17
N2 - Organic semiconductors are being increasingly used for a variety of biological applications, such as biochemical sensors, drug delivery, and neural interfaces. However, the poor adhesion of cells to the typically hydrophobic, neutrally charged and low surface energy of semiconducting thin films limit their use in in vitro, cell integrated bioelectronic devices. In this work, we investigate the influence of lysine side chain units incorporated in a diketopyrrolopyrrole (DPP) semiconducting polymer on neural cell adhesion and growth, as well as evaluate their function in electrical devices. Synthesis of such biofunctionalized polymers obviates the need of biological coating steps while changing the surface physiochemistry, promising for applications in bioelectronics.
AB - Organic semiconductors are being increasingly used for a variety of biological applications, such as biochemical sensors, drug delivery, and neural interfaces. However, the poor adhesion of cells to the typically hydrophobic, neutrally charged and low surface energy of semiconducting thin films limit their use in in vitro, cell integrated bioelectronic devices. In this work, we investigate the influence of lysine side chain units incorporated in a diketopyrrolopyrrole (DPP) semiconducting polymer on neural cell adhesion and growth, as well as evaluate their function in electrical devices. Synthesis of such biofunctionalized polymers obviates the need of biological coating steps while changing the surface physiochemistry, promising for applications in bioelectronics.
UR - http://hdl.handle.net/10754/628480
UR - https://pubs.acs.org/doi/10.1021/acs.chemmater.8b02804
UR - http://www.scopus.com/inward/record.url?scp=85052908134&partnerID=8YFLogxK
U2 - 10.1021/acs.chemmater.8b02804
DO - 10.1021/acs.chemmater.8b02804
M3 - Article
SN - 0897-4756
VL - 30
SP - 6164
EP - 6172
JO - Chemistry of Materials
JF - Chemistry of Materials
IS - 17
ER -