In vitro Anti-atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds

Eleni Sioriki, Ronan Lordan, Fady Nahra, Kristof Van Hecke, Ioannis Zabetakis, Steven P. Nolan

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC⋅H][AuCl2] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*⋅H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.
Original languageEnglish (US)
Pages (from-to)2484-2487
Number of pages4
Issue number23
StatePublished - Nov 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry
  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)


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