TY - JOUR
T1 - In vitro Anti-atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds
AU - Sioriki, Eleni
AU - Lordan, Ronan
AU - Nahra, Fady
AU - Van Hecke, Kristof
AU - Zabetakis, Ioannis
AU - Nolan, Steven P.
N1 - KAUST Repository Item: Exported on 2022-06-09
Acknowledged KAUST grant number(s): OSR-2015-CCF-1974-03
Acknowledgements: This work was supported in part by the Department of Biological Sciences, University of Limerick, Limerick, Ireland. We thank King Saud University (Distinguished Scientist Fellowship Program) and King Abdullah University of Science and Technology (Award No. OSR-2015-CCF-1974-03) for their support.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC⋅H][AuCl2] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*⋅H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.
AB - The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC⋅H][AuCl2] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*⋅H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.
UR - http://hdl.handle.net/10754/678810
UR - https://onlinelibrary.wiley.com/doi/10.1002/cmdc.201800601
UR - http://www.scopus.com/inward/record.url?scp=85057473574&partnerID=8YFLogxK
U2 - 10.1002/cmdc.201800601
DO - 10.1002/cmdc.201800601
M3 - Article
SN - 1860-7187
VL - 13
SP - 2484
EP - 2487
JO - ChemMedChem
JF - ChemMedChem
IS - 23
ER -