In vivo local determination of tissue optical properties

Frederic Bevilacqua*, D. Piguet, P. Marquet, J. D. Gross, B. J. Tromberg, C. Depeursinge

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

13 Scopus citations


Local and superficial optical characterization of biological tissues can be achieved by measuring the spatially resolved diffuse reflectance at small source-detector separations. The sensitivity of the signal to the phase function, absorption and scattering coefficients were studied using Monte Carlo simulations. Measurements of spatially resolved reflectance were performed in vivo on human brain with source-detector separations from 0.3 to 1.5 mm. Distinct optical properties were found between normal cortex, astrocytoma of optic nerve and normal optic nerve.

Original languageEnglish (US)
Pages (from-to)262-268
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1997
Externally publishedYes
EventProceedings of Photon Propagation in Tissues III - San Remo, Italy
Duration: Sep 6 1997Sep 8 1997


  • Absorption coefficient
  • Optical biopsy
  • Optical properties
  • Scattering coefficient
  • Tissue optics
  • Turbid media

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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