In vivo measurement of dye concentration using an evanescent-wave optical sensor

P. Poscio; Y. Emery; P. Bauerfeind; Ch Depeursinge

doi:10.1007/BF02524685

In vivo measurement of dye concentration using an evanescent-wave optical sensor

P. Poscio^*, Y. Emery, P. Bauerfeind, Ch Depeursinge

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A miniaturised evanescent-wave optical sensor is proposed for in vivo measurement of dye concentrations. It enables a continuous monitoring of the optical-dye attenuation or fluorescence spectra between 380 and 650 nm. The sensor is constructed with polished fibres: the cladding of a single-mode fibre is removed by longitudinal polishing. The proximity of the core to the medium favours penetration of the evanescent part of the modal field into the bio fluid. The dimensions of the probe permit several potential applications: for example, insertion into hypodermic needles for spectroscopic analysis of tissues and blood. In the paper, a gastro-enterologic application of the sensor introduced into a catheter is reported. In vivo tests demonstrate the feasibility of quantitative measurement of dye clearance in the gastro-oesophageal tract.

Original language	English (US)
Pages (from-to)	362-366
Number of pages	5
Journal	Medical & Biological Engineering & Computing
Volume	32
Issue number	4
DOIs	https://doi.org/10.1007/BF02524685
State	Published - Jul 1994
Externally published	Yes

Keywords

Clearance
Dye tracer
Evanescent wave
Gastro-esophageal tract
Optical sensor

ASJC Scopus subject areas

Biomedical Engineering
Computer Science Applications

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10.1007/BF02524685

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title = "In vivo measurement of dye concentration using an evanescent-wave optical sensor",

abstract = "A miniaturised evanescent-wave optical sensor is proposed for in vivo measurement of dye concentrations. It enables a continuous monitoring of the optical-dye attenuation or fluorescence spectra between 380 and 650 nm. The sensor is constructed with polished fibres: the cladding of a single-mode fibre is removed by longitudinal polishing. The proximity of the core to the medium favours penetration of the evanescent part of the modal field into the bio fluid. The dimensions of the probe permit several potential applications: for example, insertion into hypodermic needles for spectroscopic analysis of tissues and blood. In the paper, a gastro-enterologic application of the sensor introduced into a catheter is reported. In vivo tests demonstrate the feasibility of quantitative measurement of dye clearance in the gastro-oesophageal tract.",

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author = "P. Poscio and Y. Emery and P. Bauerfeind and Ch Depeursinge",

year = "1994",

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volume = "32",

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AU - Poscio, P.

AU - Emery, Y.

AU - Bauerfeind, P.

AU - Depeursinge, Ch

PY - 1994/7

Y1 - 1994/7

N2 - A miniaturised evanescent-wave optical sensor is proposed for in vivo measurement of dye concentrations. It enables a continuous monitoring of the optical-dye attenuation or fluorescence spectra between 380 and 650 nm. The sensor is constructed with polished fibres: the cladding of a single-mode fibre is removed by longitudinal polishing. The proximity of the core to the medium favours penetration of the evanescent part of the modal field into the bio fluid. The dimensions of the probe permit several potential applications: for example, insertion into hypodermic needles for spectroscopic analysis of tissues and blood. In the paper, a gastro-enterologic application of the sensor introduced into a catheter is reported. In vivo tests demonstrate the feasibility of quantitative measurement of dye clearance in the gastro-oesophageal tract.

AB - A miniaturised evanescent-wave optical sensor is proposed for in vivo measurement of dye concentrations. It enables a continuous monitoring of the optical-dye attenuation or fluorescence spectra between 380 and 650 nm. The sensor is constructed with polished fibres: the cladding of a single-mode fibre is removed by longitudinal polishing. The proximity of the core to the medium favours penetration of the evanescent part of the modal field into the bio fluid. The dimensions of the probe permit several potential applications: for example, insertion into hypodermic needles for spectroscopic analysis of tissues and blood. In the paper, a gastro-enterologic application of the sensor introduced into a catheter is reported. In vivo tests demonstrate the feasibility of quantitative measurement of dye clearance in the gastro-oesophageal tract.

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KW - Dye tracer

KW - Evanescent wave

KW - Gastro-esophageal tract

KW - Optical sensor

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In vivo measurement of dye concentration using an evanescent-wave optical sensor

Abstract

Keywords

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