Induced pluripotent stem cells and reprogramming: Seeing the science through the hype

Juan Carlos Izpisúa Belmonte; James Ellis; Konrad Hochedlinger; Shinya Yamanaka

doi:10.1038/nrg2700

Induced pluripotent stem cells and reprogramming: Seeing the science through the hype

Juan Carlos Izpisúa Belmonte, James Ellis, Konrad Hochedlinger, Shinya Yamanaka

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Abstract

No-one can have failed to notice the splash that induced pluripotent stem (iPS) cells have made in the few years since somatic cells were first reprogrammed to pluripotency. But what is their real promise, where should research efforts be focused, and are we at a stage where we can replace embryonic stem cells? Four pioneering iPS cell researchers offer their personal insights into these and other questions of current debate. As well expressing hope for the improved understanding and treatment of human disease, they urge caution over safety and propose the establishment of iPS cell banks.

Original language	English (US)
Pages (from-to)	878-883
Number of pages	6
Journal	Nature Reviews Genetics
Volume	10
Issue number	12
DOIs	https://doi.org/10.1038/nrg2700
State	Published - Dec 2009
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nrg2700

Cite this

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abstract = "No-one can have failed to notice the splash that induced pluripotent stem (iPS) cells have made in the few years since somatic cells were first reprogrammed to pluripotency. But what is their real promise, where should research efforts be focused, and are we at a stage where we can replace embryonic stem cells? Four pioneering iPS cell researchers offer their personal insights into these and other questions of current debate. As well expressing hope for the improved understanding and treatment of human disease, they urge caution over safety and propose the establishment of iPS cell banks.",

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AB - No-one can have failed to notice the splash that induced pluripotent stem (iPS) cells have made in the few years since somatic cells were first reprogrammed to pluripotency. But what is their real promise, where should research efforts be focused, and are we at a stage where we can replace embryonic stem cells? Four pioneering iPS cell researchers offer their personal insights into these and other questions of current debate. As well expressing hope for the improved understanding and treatment of human disease, they urge caution over safety and propose the establishment of iPS cell banks.

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Induced pluripotent stem cells and reprogramming: Seeing the science through the hype

Abstract

ASJC Scopus subject areas

UN SDGs

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