TY - JOUR
T1 - Induced pluripotent stem cells and reprogramming
T2 - Seeing the science through the hype
AU - Izpisua Belmonte, Juan Carlos
AU - Ellis, James
AU - Hochedlinger, Konrad
AU - Yamanaka, Shinya
PY - 2009/12/1
Y1 - 2009/12/1
N2 - No-one can have failed to notice the splash that induced pluripotent stem (iPS) cells have made in the few years since somatic cells were first reprogrammed to pluripotency. But what is their real promise, where should research efforts be focused, and are we at a stage where we can replace embryonic stem cells? Four pioneering iPS cell researchers offer their personal insights into these and other questions of current debate. As well expressing hope for the improved understanding and treatment of human disease, they urge caution over safety and propose the establishment of iPS cell banks.
AB - No-one can have failed to notice the splash that induced pluripotent stem (iPS) cells have made in the few years since somatic cells were first reprogrammed to pluripotency. But what is their real promise, where should research efforts be focused, and are we at a stage where we can replace embryonic stem cells? Four pioneering iPS cell researchers offer their personal insights into these and other questions of current debate. As well expressing hope for the improved understanding and treatment of human disease, they urge caution over safety and propose the establishment of iPS cell banks.
UR - http://www.scopus.com/inward/record.url?scp=70450224866&partnerID=8YFLogxK
U2 - 10.1038/nrg2700
DO - 10.1038/nrg2700
M3 - Review article
C2 - 19859062
AN - SCOPUS:70450224866
SN - 1471-0056
VL - 10
SP - 878
EP - 883
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 12
ER -
